Membranotropic Property and Antibiofilm Efficacy of Novel Phosphonium Derivatives Bearing Phenolic Moiety

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Abstract

New derivatives of phosphonium salts (Z)-(2-(2-hydroxy-5-chlorphenyl)-2-phenylethenyl)octyldiphenyl-phosphonium chloride (PP8) and (2-hydroxybenzyl)dodecyldiphenylphosphonium chloride (6.5) were found to cause depolarization and permeabilization of the bacterial membrane. The ability of phosphonium salts to prevent the formation of Staphylococcus aureus biofilms and to disrupt them was demonstrated. Furthermore, the results demonstrated that the substances do not cause resistance development in the S. aureus strain. Finally, compound PP8 did not demonstrate mutagenic properties in the Ames test using strains of Salmonella typhimurium TA100 and S. typhimurium TA98.

About the authors

A. P. Lyubina

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

A. D. Voloshina

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

S. K. Amerkhanova

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

A. S. Sapunova

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

D. A. Tatarinov

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Email: aplyubina@gmail.com
Kazan, 420088 Russia

V. F. Mironov

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences

Author for correspondence.
Email: aplyubina@gmail.com
Kazan, 420088 Russia

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