Microbial 1,2-dehydrogenation of 6 Alpha-Methylhydrocortisone 11-trifluoroacetate

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Abstract

Transformation of 11-trifluoroacetate 6α-methylhydrocortisone (11-TFA MHC) by cells of actinobacteria Arthrobacter (Nocardioides) was carried out in the presence of α-cyclodextrin (α-CD). The composition and dynamics of the transformation products accumulation in the culture medium at various pH values and the ratio of α-CD/substrate were studied. It was shown that the addition of α-CD to the transformation medium at pH less than 7 promotes an increase in the rate of 1,2-dehydrogenation with the formation of 6 α-methylprednisolone 11-trifluoroacetate (11-TFA MPL). At pH over 7, the primary process is the hydrolysis of the 11β-trifluoroacetyloxy group. In this case, the participation of α-CD in these processes as an acceptor of the trifluoroacetyl ion is not excluded.

About the authors

T. S. Savinova

Erisman FSCH of Rospotrebnadzor

Author for correspondence.
Email: tatiana_savinova@rambler.ru
Russia, 141014, Mytishchi

A. Yu. Arinbasarova

Skryabin Institute of Biochemistry and Physiology of Microorganisms, Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Science”

Email: tatiana_savinova@rambler.ru
Russia, 142290, Pushchino

A. V. Kazantsev

Lomonosov Moscow State University, Faculty of Chemistry

Email: tatiana_savinova@rambler.ru
Russia, 119991, Moscow

O. S. Savinova

Bach Institute of Biochemistry, Biotechnology Research Center of Russian Academy of Sciences

Email: tatiana_savinova@rambler.ru
Russia, 119071, Moscow

N. V. Lukashev

Lomonosov Moscow State University, Faculty of Chemistry

Email: tatiana_savinova@rambler.ru
Russia, 119991, Moscow

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Copyright (c) 2023 Т.С. Савинова, А.Ю. Аринбасарова, А.В. Казанцев, О.С. Савинова, Н.В. Лукашёв

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