Method for Producing 5-Cyano-2-Methyl-n-(2-Methylphenyl)-4-(4-Nitrophenyl)-6-Thioxo-1,6-Dihydropyridine-3-Carboxamide Derivatives

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Abstract

The multicomponent interaction of 4-nitrobenzaldehyde, cyanothioacetamide, N-(2-methylphenyl)-3-oxobutanamide and alkyl halides upon boiling in ethanol in the presence of twice the amount of potassium hydroxide produced derivatives of 5-cyano-2-methyl-N-(2-methylphenyl)-4-(4-nitrophenyl)-6-thioxo-1,6-dihydropyridine-3-carboxamide – 2-alkylthiopyridines and 3-aminothieno[2,3-b]pyridines, with yields of 64–91%.

About the authors

B. S Krivokolysko

V. Dahl Lugansk State University; St. Luke Lugansk State Medical University

ORCID iD: 0000-0002-3181-7609
Chemex Lab Lugansk, Russia; Lugansk, Russia

D. V Nikitenko

Institute of Physical Organic Chemistry and Coal Chemistry

ORCID iD: 0000-0001-6902-8114
Donetsk, Russia

S. G Krivokolysko

V. Dahl Lugansk State University; St. Luke Lugansk State Medical University

Email: ksg-group-lugansk@mail.ru
ORCID iD: 0000-0001-9879-9217
Chemex Lab Lugansk, Russia; Lugansk, Russia

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