Synthesis of Grico Lactone and Its Enantiomer

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Abstract

A two-step transition from individual diastereomeric 2,2-dichloro-2-[(1R,5S)- and 2,2-dichloro-2-[(1S,5R)-5-hydroxycyclopent-2-en-1-yl]-N-[(1R)-1-phenylethyl]acetamides to the enantiomers of Grieco lactone is described with a total yield of 77%.

About the authors

Z. R Valiullina

Ufa Institute of Chemistry UFRC RAS

Email: valiullina.zulya@mail.ru
ORCID iD: 0000-0002-6868-4870
Ufa, Russia

Z. R Makaev

Ufa Institute of Chemistry UFRC RAS

ORCID iD: 0000-0002-0958-3164
Ufa, Russia

N. A Ivanova

Ufa Institute of Chemistry UFRC RAS

ORCID iD: 0000-0002-3101-1285
Ufa, Russia

M. S Miftakhov

Ufa Institute of Chemistry UFRC RAS

ORCID iD: 0000-0002-0269-7484
Ufa, Russia

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