Synthesis of 7-(Ethoxymethyl)-4',4'-Dimethyl-2-(3-Nitrophenyl)-2',6',8-Trioxo-5,7-Diazaspiro[Bicyclo[3.3.1]Nonane-3,1'-Cyclohexane]-1-Carbonitrile

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Abstract

Based on 2-amino-7,7-dimethyl-4-(3-nitrophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile and formalin when heated in ethanol was obtained 7-(ethoxymethyl)-4',4'-dimethyl-2-(3-nitrophenyl)-2',6',8-trioxo-5,7-diazaspiro[bicyclo[3.3.1]nonane-3,1'-cyclohexane]-1-carbonitrile, the structure of which has been studied using spectral methods and X-ray diffraction analysis.

About the authors

A. V Churakov

N.S. Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

ORCID iD: 0000-0003-3336-4022
Moscow, Russia

B. S Krivokolysko

Chemex Lab, V. Dahl Lugansk State University

ORCID iD: 0000-0002-3181-7609
Lugansk, Russia

S. G Krivokolysko

Chemex Lab, V. Dahl Lugansk State University

Email: ksg-group-lugansk@mail.ru
ORCID iD: 0000-0001-9879-9217
Lugansk, Russia

References

  1. Vitaku E., Smith D.T., Njardarson J.T. J. Med. Chem. 2014, 57 (24), 10257–10274. https://doi.org/10.1021/jm501100b
  2. Khamitova A.E., Berillo D.A. Drug Develop. Registr. 2023, 12 (2), 44–54. https://doi.org/10.33380/2305-2066-2023-12-2-44-54
  3. De la Torre B.G., Albericio F. Molecules. 2022, 27 (3), 1075. https://doi.org/10.3390/molecules27031075
  4. Pranabes B., Koyel P., Sanjay P., Asish R.D. Tetrahedron Lett. 2012, 53 (35), 4687–4691. https://doi.org/10.1016/j.tetlet.2012.06.086
  5. Zhilan L., Xueli Z., Xinkui Y., Yuan G. Tetrahedron. 2012, 68 (33), 6759–6764. https://doi.org/10.1016/j.tet.2012.05.089
  6. Adeleh Moshtaghi Z., Parisa G., Azita P. Lett. Org. Chem. 2022, 19 (11), 993–998. https://doi.org/10.2174/1570178619666220209154646
  7. Shohreh A., Abolghasem D., Mehdi P., Hossein B. J. Heterocycl. Chem. 2017, 54 (2), 1437–1441. https://doi.org/10.1002/jhet.2729
  8. Zhong-Xia W., Bei L., Zheng X., Li-Zhuang C., Guang-Fan H. J. Chem. Res. 2014, 38 (8), 480–485. https://doi.org/10.3184/174751914X14053476598397
  9. Prasun M., Asish R.D. RSC Adv. 2015, 6 (1), 132–139. https://doi.org/10.1039/C5RA24510A
  10. Nagarajan Panneer S., Thelagathoti Hari B., Paramasivan T.P. Tetrahedron. 2009, 65 (41), 8524–8530. https://doi.org/10.1016/j.tet.2009.08.025
  11. Marco-Contelles J., Leon R., Rios C., Garcia A.G., Lopez M.G., Villarroya M. Bioorg. Med. Chem. 2006, 14 (24), 8176–8185. https://doi.org/10.1016/j.bmc.2006.09.025
  12. Karimi N., Davoodnia A., Pordel M. Heterocyclic Commun. 2018, 24 (1), 31–35. https://doi.org/10.1515/hc-2017-0228
  13. Leon R., Garcia A.G., Marco-Contelles J. J. Chem. Res. 2006, 8, 536–538. https://doi.org/10.3184/030823406778256324
  14. Dotsenko V.V., Frolov K.A., Chigorina E.A., Khrustaleva A.N., Bibik E.Yu., Krivokolysko S.G. Russ. Chem. Bull. 2019, 68 (4), 691–707. https://doi.org/10.1007/s11172-019-2476-5
  15. Undale K.A., Park Y.K., Park K.P., Dagade D.H., Pore D.M. Synlett. 2011, 6, 791–796. https://doi.org/10.1055/s-0030-1259924
  16. Sheldrick G.M. SADABS. Program for scaling and correction of area detector data. University of Göttingen. Germany, 1997.
  17. Sheldrick G.M. Acta Crystallogr. Sect A. 2008, 64 (1), 112–122. https://doi.org/10.1107/S0108767307043930

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