Synthesis and Antioxidant, Antihypertensive, Sympathoand Adrenolytic Activity of New Amides, Amines and Ariloxyaminopanols Including a Fragment of 4-(4-Methoxyphenyl)Tetrahydro-2h-Pyrane

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Abstract

By reacting 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylamine with acid chlorides of different acids and the acid chloride of 4-(4-methoxyphenyl)tetrahydro-2H-pyrancarboxylic acid with various amines, amides were synthesized, which reduced with lithium aluminum hydride to the corresponding secondary amines. New aryloxypropanolamines were synthesized by opening aryloxymethyloxiranes with 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylamine, and by adding the same amine to the double bond of acrylonitrile and acrylamide, the nitrile and amide of 3-(((4-(4-methoxyphenyl)tetrahydro- 2H-pyran-4-yl)methyl)amino)propionic acid were isolated. The biological activity of the synthesized compounds was studied.

About the authors

A. A. Aghekyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-6151-4951
prosp. Azatutyan, 26, Yerevan, 0014 Armenia

G. Z. Sargsyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru
prosp. Azatutyan, 26, Yerevan, 0014 Armenia

S. A. Harutyunyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru
ORCID iD: 0000-0003-3748-6975
prosp. Azatutyan, 26, Yerevan, 0014 Armenia

N. A. Pahutyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-3864-8705
prosp. Azatutyan, 26, Yerevan, 0014 Armenia

H. A. Hunanyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-6954-0297
prosp. Azatutyan, 26, Yerevan, 0014 Armenia

H. V. Gasparyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-8555-3733
prosp. Azatutyan, 26, Yerevan, 0014 Armenia

G. G. Mkryan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-9879-9524
prosp. Azatutyan, 26, Yerevan, 0014 Armenia

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