Synthesis and Antihypoxic Activity of Disubstituted Derivatives of 1,2,4-Triazole Including Oxygen-Containing Heterocycles

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Authors: Vardanyan S.O.¹, Avagyan A.S.¹, Sargsyan A.B.¹, Panosyan H.A.¹, Harutyunyan S.A.¹, Gasparyan H.V.¹, Aghekyan A.A.¹
Affiliations:
1. The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Issue: Vol 61, No 9 (2025)
Pages: 1348-1353
Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://journals.rcsi.science/0514-7492/article/view/380405
DOI: https://doi.org/10.7868/S3034630425090085
ID: 380405

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Abstract
About the authors
References
Supplementary files
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Abstract

The reaction of 4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carboxylic acid chloride with thiosemicarbazide gave corresponding hydrazinocarbothioamide, which was cyclized under the action of KOH to 5-(4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-yl)-4H-1,2,4-triazole-3-thiol. By reacting the latter with aryland heterylalkyl chlorides, as well as N-substituted chloroacetamides, new S-substituted derivatives were synthesized. The antihypoxic activity of the synthesized compounds was studied.

Keywords

1,4-benzodioxane, 1,2,4-triazole, thiosemicarbazide, arylalkyl chloride, antihypoxic activity

About the authors

S. O. Vardanyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: avagal@mail.ru
ORCID iD: 0000-0003-4582-7629
ul. Azatutyana, 26, Yerevan, 0014 Armenia

A. S. Avagyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: avagal@mail.ru
ORCID iD: 0000-0002-7148-3666
ul. Azatutyana, 26, Yerevan, 0014 Armenia

A. B. Sargsyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: avagal@mail.ru
ORCID iD: 0000-0001-7115-9164
ul. Azatutyana, 26, Yerevan, 0014 Armenia

H. A. Panosyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: avagal@mail.ru
ORCID iD: 0000-0001-8311-6276
ul. Azatutyana, 26, Yerevan, 0014 Armenia

S. A. Harutyunyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: avagal@mail.ru
ORCID iD: 0000-0003-3748-6975
ul. Azatutyana, 26, Yerevan, 0014 Armenia

H. V. Gasparyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: avagal@mail.ru
ORCID iD: 0000-0002-8555-3733
ul. Azatutyana, 26, Yerevan, 0014 Armenia

A. A. Aghekyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: avagal@mail.ru
ORCID iD: 0000-0001-6151-4951
ul. Azatutyana, 26, Yerevan, 0014 Armenia

References

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Jat Lala Ram, Sharma V., Agarwal R. J. Pharm. Sci. Rev. Res. 2023, 79, 84–91; Article № 16; https://globalresearchonline.net/ijpsrr/v79-1/16.pdf
Saleem D., Hamdi M.D., Kareem A. Al Mustansiriyah J. Pharm. Sci. 2022, 22, 65–81. http://doi.org/10.32947/ajps.v22i3.890
Айрапетян Г.К., Акопян М.Г., Арустамян Ж.С., Маркарян Э.А. ХГС. 1993, 5, 677–680.
Ширинян Э.А., Мартиросян О.М., Арутюнян С.А., Атаян Т.К. Физиол. ж. СССР. 1990, 76, 1197–1202.

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