Interaction of 5,7-Dihydroxycoumarins with Pyrimidines

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Abstract

The study of 5,7-dihydroxycoumarins as nucleophilic agents in the SN H reaction with pyrimidines showed that the reaction does not stop at the stage of σH-adduct formation as the intermediate in the SN H mechanism, but proceeds further with annulation of the 1,3,5-oxadiazazine ring in moderate to excellent yields. The structures of the obtained compounds were confirmed using NMR and X-ray diffraction. A primary in vitro assessment of antitumor activity was performed.

About the authors

R. F Fatykhov

Ural Federal University named after the first President of Russia B.N. Yeltsin

Ekaterinburg, Russia

I. A Khalymbadzha

Ural Federal University named after the first President of Russia B.N. Yeltsin

Ekaterinburg, Russia

A. P Potapova

Ural Federal University named after the first President of Russia B.N. Yeltsin

Ekaterinburg, Russia

V. V Melekhin

Ural Federal University named after the first President of Russia B.N. Yeltsin; Ural State Medical University

Ekaterinburg, Russia

A. V Paramonova

Ural Federal University named after the first President of Russia B.N. Yeltsin

Ekaterinburg, Russia

D. S Kopchuk

Ural Federal University named after the first President of Russia B.N. Yeltsin; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: dkopchuk@mail.ru
Ekaterinburg, Russia; Ekaterinburg, Russia

P. A Slepukhin

Ural Federal University named after the first President of Russia B.N. Yeltsin; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Ekaterinburg, Russia; Ekaterinburg, Russia

V. G Kartsev

InterBioScreen, Ltd.

Chernogolovka, Russia

O. N Chupakhin

Ural Federal University named after the first President of Russia B.N. Yeltsin; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Ekaterinburg, Russia; Ekaterinburg, Russia

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