Late-Stage C–H Functionalization of Nimesulide via (Nimesulide)(3,5-Dimethyl-4-Isoxazoly)Jodonium Salt Formation

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Abstract

The reaction of N-methylated Nimesulide with Koiser’s reagent based on 4-iodo-3,5-dimethylisoxazole (DMIX-I(OH)OTs) yielded the corresponding iodonium salt. The interaction of this salt with S, O, and N-nucleophiles resulted in the production of functionalized derivatives of Nimesulide.

About the authors

D. I. Bugaenko

Moscow State University

Email: bugaenko@org.chem.msu.ru
ORCID iD: 0000-0002-5028-7244
Moscow, Russia

A. V. Karchava

Moscow State University

Email: karchava@org.chem.msu.ru
ORCID iD: 0000-0001-9008-644X
Moscow, Russia

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