Alkylation of Ethyl 2-Aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with Benzyl Halides

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Abstract

Alkylation of ethyl 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with substituted benzyl hal-ides led to the selective formation of O-alkoxy derivatives. Products of N-alkylation(1-alkylimidazole 3-oxides) could be obtained by condensation reaction from acyclic starting compounds. If a 2-hydroxy-phenyl moiety was present in position 2 of imidazole ring, then monoalkylation proceeded selectively at hydroxy group of the nitrogen atom of heterocycle.

About the authors

P. A Nikitina

D.I. Mendeleev University of Chemical Technology of Russia

Email: polinandrevna@yandex.ru
Moscow, Russia

I. A Os’kina

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Science

Novosibirsk, Russia

E. B Nikolaenkova

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Science

Novosibirsk, Russia

E. A Kulikova

D.I. Mendeleev University of Chemical Technology of Russia

Moscow, Russia

V. S Miroshnikov

D.I. Mendeleev University of Chemical Technology of Russia

Moscow, Russia

V. P Perevalov

D.I. Mendeleev University of Chemical Technology of Russia

Moscow, Russia

A. Ya Tikhonov

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Science

Novosibirsk, Russia

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