Adamantoylation of CH-Acids

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Abstract

Acylation reactions of CH-acids have been studied and an efficient approach to the synthesis of (1-adamantyl)methyl ketone directly from 1-adamantylcarbonyl chlorides has been developed. The proposed method includes successive reactions of carboxylic acid chlorides with diethylmalonate in the presence of sodium hydroxide, further hydrolysis of intermediate ketodiesters in an acidic medium, and decarboxylation.

About the authors

Yu. N. Klimochkin

Samara State Technical University

Samara, Russia

I. R. Korzhev

Samara State Technical University

Samara, Russia

E. A. Ivleva

Samara State Technical University

Email: ivleva.ea@samgtu.ru
Samara, Russia

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