Synthesis of Substituted Thienopyrimidinones Based on 2-Amino-4-(1,4-benzodioxan-2-yl) Thiophene-3-carboxylic Acid Ethyl Ester

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

The previously obtained N-arylamides of 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylic acid ethyl ester were cyclized to 2-aryl-substituted 3-aminothienopyrimidin-4-ones by the action of hydrazine hydrate. By condensation of the starting amino ester with chloroacetic acid chloride was obtained chloramide, which was converted by the action of piperidine and morpholine into the corresponding aminomethylamides. The latters were also subjected to cyclization with hydrazine hydrate to 3-aminothienopyrimidin-4-one derivatives with aminomethyl substituents in the second position. The antihypoxic activity of the synthesized compounds was studied.

Авторлар туралы

S. Vardanyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

A. Avagyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: avagal@mail.ru
Yerevan, Armenia

A. Sargsyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

S. Harutyunyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

H. Gasparyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

A. Aghekyan

The Scienctific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

Әдебиет тізімі

  1. The use of stems in the selection of International Nonprietary Names (INN) for pharmaceutical substances. Geneva, WHO, 2018.
  2. Giri R.S., Thaker H. M., Giordano T., Williams J., Rogers D, Vasu K.K., Sudarsanam V. Bioorg. Med. Chem. 2010, 18, 2796. doi: 10.1016/j.bmc.2010.01.007
  3. Tang J., Huber A.D, Pineda D. L., Boschert K.N., Wolf J.J., Kankanala J., Xie J., Sarafianos S.G., Wang Zh. Eur. J. Med. Chem. 2019, 164, 179. doi: 10.1016/j.ejmech.2018.12.047
  4. Jin X., Merrett J., Tong Sh., Flower B., Xie J., Yu R., Tian Sh., Gao L., Zhao J., .Wang X, Jiang T., Proud Ch.G. Eur. J. Med. Chem. 2019, 162, 735–751. doi 10.1016/j. ejmech. 2018.10.070
  5. Vardanyan S.O., Aghekyan A.A., Avagyan A.S., Harutyunyan S.A., Gasparyan H.V. Russ. J. Org. Chem. 2019, 55, 598–601. doi: 10.1134/S1070428019050038
  6. Арутюнян С.А. Вестник МАНЭБ. 2005, 10, 169–173.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Russian Academy of Sciences, 2025

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).