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Synthesis and properties of 1,3-disubstituted ureas and its isostering analogs containing polycyclic fragments: XIX. Exo-isomers of 1-(1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)-3-R ureas and thioureas
- Authors: Burmistrov V.V.1,2, Kuznetsov Y.P.1,2, Novikov V.V.1,2, Abbas Saeef M.H.1, Davidenko A.V.1, Vernigora A.A.1, Butov G.M.1,2
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Affiliations:
- Volgograd State Technical University
- Volzhsky polytechnic institute (branch) VSTU
- Issue: Vol 61, No 3 (2025)
- Pages: 221-229
- Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
- URL: https://journals.rcsi.science/0514-7492/article/view/304569
- DOI: https://doi.org/10.31857/S0514749225030017
- EDN: https://elibrary.ru/esycgf
- ID: 304569
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Abstract
For a comprehensive assessment of the enantiomeric stereospecificity of human soluble epoxide hydrolase (hsEH), 1,3-disubstituted ureas and thioureas containing a bornyl fragment in their structure were synthesized according to the reaction exo-(R or S)-1,1,7-trimethylbicyclo[2.2.1]heptane-2-amine with aromatic isocyanates and isothiocyanates with yields up to 99%. Synthesized compounds are promising inhibitors of hsEH.
About the authors
V. V. Burmistrov
Volgograd State Technical University; Volzhsky polytechnic institute (branch) VSTU
Email: butov@post.volpi.ru
Leninskii prosp., 28, Volgograd, 400005 Russia; ul. Engelsa, 42a, Volzhsky, 404121 Russia
Y. P. Kuznetsov
Volgograd State Technical University; Volzhsky polytechnic institute (branch) VSTU
Email: butov@post.volpi.ru
Leninskii prosp., 28, Volgograd, 400005 Russia; ul. Engelsa, 42a, Volzhsky, 404121 Russia
V. V. Novikov
Volgograd State Technical University; Volzhsky polytechnic institute (branch) VSTU
Email: butov@post.volpi.ru
Leninskii prosp., 28, Volgograd, 400005 Russia; ul. Engelsa, 42a, Volzhsky, 404121 Russia
M. H. Abbas Saeef
Volgograd State Technical University
Email: butov@post.volpi.ru
Leninskii prosp., 28, Volgograd, 400005 Russia
A. V. Davidenko
Volgograd State Technical University
Email: butov@post.volpi.ru
Leninskii prosp., 28, Volgograd, 400005 Russia
A. A. Vernigora
Volgograd State Technical University
Email: butov@post.volpi.ru
Leninskii prosp., 28, Volgograd, 400005 Russia
G. M. Butov
Volgograd State Technical University; Volzhsky polytechnic institute (branch) VSTU
Author for correspondence.
Email: butov@post.volpi.ru
Leninskii prosp., 28, Volgograd, 400005 Russia; ul. Engelsa, 42a, Volzhsky, 404121 Russia
References
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