Synthesis and antiproliferative activity of 2-aryl-aminopyrimidine amides of benzimidazole-substituted phenylcarboxylic acid – new potential protein kinase inhibitors

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Abstract

The results of a study on the synthesis and antiproliferative activity of new phenylcarboxylic acid amides, the structure of which contains pharmacophoric fragments of nitrogen-containing heterocycles – 2-aminopyrimidine, benzimidazole, pyridine, are presented. The synthesis was carried out by acylation of substituted 2-arylaminopyrimidine phenylenediamines with p-benzimidazole-phenylcarboxylic acid chloride or by aminolysis of p-benzimidazolephenylcarboxylic acid with 2-arylaminopyrimidinephenylenediamines. The potential inhibitory activity of the synthesized amides was assessed by in vitro screening of the compounds for antiproliferative activity in models of stable human tumor cell lines K562, HL-60, RPMI 1788, HeLa.

About the authors

E. V. Koroleva

Institute of Chemistry of New Materials, NAS of Belarus

Email: evk@ichnm.by
Minsk, 220084, ul. F. Skoriny, 36

A. L. Ermolinskaya

Institute of Chemistry of New Materials, NAS of Belarus

Minsk, 220084, ul. F. Skoriny, 36

Z. V. Ignatovich

Institute of Chemistry of New Materials, NAS of Belarus

Minsk, 220084, ul. F. Skoriny, 36

O. V. Panibrat

Institute of Bioorganic Chemistry, NAS of Belarus

Minsk, 220084, ul. Kuprevicha, 5

T. K. D. Hoang

Institute of Chemical Technology, Vietnam Academy of Science and Technology

Ho Chi Minh City, 70000, No.1A, Thanh Loc Street, Thanh Loc Ward, District 12

T. K. C. Huynh

Institute of Chemical Technology, Vietnam Academy of Science and Technology

Ho Chi Minh City, 70000, No.1A, Thanh Loc Street, Thanh Loc Ward, District 12

T. C. T. Nguyen

Institute of Chemical Technology, Vietnam Academy of Science and Technology

Ho Chi Minh City, 70000, No.1A, Thanh Loc Street, Thanh Loc Ward, District 12

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