Email this article Synthesis and aminomethylation of A-azepanederivatives of uvaol and betulin
- Authors: Petrova A.V1
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Affiliations:
- Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Science
- Issue: Vol 59, No 1 (2023)
- Pages: 133-138
- Section: Articles
- URL: https://journals.rcsi.science/0514-7492/article/view/144716
- DOI: https://doi.org/10.31857/S0514749223010123
- EDN: https://elibrary.ru/PGVBAZ
- ID: 144716
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Abstract
By stepwise conjugation of biologically active A-azepanobetulin or A-azepanouvaol with succinic anhydride and propargylamine, followed by a Cu-catalyzed Mannich reaction, new hybrid derivatives with an N -methylpiperazine fragment were synthesized with an average yield of 73%. The structure of the obtained compounds was established using NMR spectroscopy.
Keywords
About the authors
A. V Petrova
Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Science
Email: pnastya08@mail.ru
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