CT Arteriography in Patients with Liver Metastases from Colorectal Cancer Following Systemic Drug Therapy

V. V. Nesterova; Нестерова В. В; D. V. Nesterov; Нестеров Д. В; I. A. Burovik; Буровик И. А; S. S. Bagnenko; Багненко С. С; P. V. Balakhnin; Балахнин П. В; A. V. Kulish; Кулиш А. В; P. Yu. Grishko; Гришко П. Ю; A. S. Shmelev; Шмелев А. С; V. I. Malkevich; Малькевич В. И; E. V. Zagaynov; Загайнов Е. В; A. M. Karachun; Карачун А. М; E. A. Busko; Бусько Е. А; K. V. Kozubova; Козубова К. В; A. S. Mamontova; Мамонтова А. С; I. I. Yarmolyuk; Ярмолюк И. И

doi:10.37469/0507-3758-2025-71-6-OF-2399

CT Arteriography in Patients with Liver Metastases from Colorectal Cancer Following Systemic Drug Therapy

Authors: Nesterova V.V.¹, Nesterov D.V.¹^,2, Burovik I.A.¹^,3, Bagnenko S.S.¹^,4, Balakhnin P.V.¹, Kulish A.V.¹, Grishko P.Y.¹, Shmelev A.S.¹, Malkevich V.I.¹, Zagaynov E.V.¹^,2, Karachun A.M.¹, Busko E.A.¹^,3, Kozubova K.V.¹, Mamontova A.S.¹, Yarmolyuk I.I.¹
Affiliations:
1. N.N. Petrov National Medicine Research Center of Oncology
2. North-Western State Medical University named after I.I. Mechnikov
3. St. Petersburg State University
4. St. Petersburg State Pediatric Medical University
Issue: Vol 71, No 6 (2025)
Pages: 1362-1369
Section: ORIGINAL ARTICLES Clinical research
URL: https://journals.rcsi.science/0507-3758/article/view/380314
DOI: https://doi.org/10.37469/0507-3758-2025-71-6-OF-2399
ID: 380314

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Abstract

Introduction. Colorectal cancer ranks third in global cancer incidence. Liver metastases are present in 25 % of patients at initial diagnosis and develop in 50 % of patients following resection of the primary tumor. Aim. To develop and evaluate a CT arteriography protocol for diagnosing colorectal cancer liver metastases following chemotherapy. chemotherapy. Materials and Methods. Seven patients with colorectal cancer and liver metastases after neoadjuvant chemotherapy were included. All patients underwent CT arteriography with intra-arterial administration of 40 mliodinated contrast medium (300−320 mgiodine/ml) at 2 ml/s. Scanning was performed in two phases: arterial (22 seconds post-injection; n = 7) and portal venous (33−38 seconds; n = 6). Imaging assessment included capillary phase enhancement, metastasis visualization, peripheral rim enhancement, and severity of transient hepatic attenuation differences (THAD). Results. Nineteen liver metastases were identified. Capillary phase enhancement was achieved in 4/7 patients (57 %) at 22 seconds and all 6 patients (100 %) at 33−38 seconds. Hypervascular rim enhancement was visualized in 15 non-calcified metastases (100 %) during both phases with consistent intensity. THAD was observed in allpa- tients at 22 seconds, with reduced severity at 33−38 seconds. Conclusion. The proposed CT arteriography technique provides 100 % visualization of peripheral rim enhancement in non-calcified colorectal liver metastases after chemotherapy. The 33−38 second scan timing is preferred due to consistent capillary phase achievement and reduced perfusion artifacts while maintaining diagnostic rim enhancement quality.

Keywords

colorectal cancer, liver metastases, CT arteriography, intra-arterial contrast enhancement, rim enhancement

References

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CT Arteriography in Patients with Liver Metastases from Colorectal Cancer Following Systemic Drug Therapy

Full Text

Abstract

Keywords

About the authors

References

Supplementary files