Screening study of various immunomodulatory medicinal collections
- Authors: Imamaliev B.A.1, Alimkulova K.Z.2, Shokodirov A.R.1, Urmanova F.F.3
-
Affiliations:
- «Med Standart» Research Center
- Expertise and Standardization of Medicines, Medical Devices and Medical Equipment» under the Ministry of Health of the Republic of Uzbekistan
- Tashkent Pharmaceutical Institute
- Issue: Vol 72, No 3 (2023)
- Pages: 41-46
- Section: Pharmacology: Experiment and clinic
- URL: https://journals.rcsi.science/0367-3014/article/view/252961
- DOI: https://doi.org/10.29296/25419218-2023-03-07
- ID: 252961
Cite item
Open Access
Access granted
Subscription Access
Abstract
Introduction. At present, it has become clear that in almost all human diseases, both infectious and non-infectious nature, there are changes in the functioning of the immune system.
Based on the foregoing, it is concluded that it is necessary to develop and study immunomodulatory agents, especially immunomodulatory agents of plant origin, since immunotropic agents of plant origin act gently and practically do not cause disruptions in the immune system associated with autoimmune and autoreactive processes.
Objective: was a screening study of various immunomodulatory medicinal collections (MC).
Material and methods. The study of the immunomodulatory activity of various MCs was carried out on the model of prednisolone immunosuppression. It is known that prednisolone, like any glucocorticosteroid, has an immunosuppressive effect, and therefore is widely used in medicine to reduce immunity.
The object of the study were five different MCs in the form of a phytocollection.
Results. According to the results of the experiment, it was found that the MC – Hypericum perforatum (herb) – 3,0 g, Glycyrrhiza glabra (roots) – 3,0 g, Arctium lappa (roots) – 3,0 g, Taraxacum officinale (roots) – 3,0 g, Quercus robur (bark)– 3,0 g, Juglans regia (leaves) – 3,0 g, Urtica dioica (leaves) – 2,0 g, Melissa officinalis (herb) – 1,0 g, Chamomilla officinalis (flowers) – 1,0 g, Salvia officinalis (leaves) – 1,0 g has the highest immunomodulatory activity and is promising for studies as an immunomodulatory agent.
Conclusion. From the five different MCs, the most promising phytocombination with promising immunomodulatory activity was determined.
Full Text
##article.viewOnOriginalSite##About the authors
Bakhtiyor Alisherovich Imamaliev
«Med Standart» Research Center
Author for correspondence.
Email: teokrat_1985@mail.ru
ORCID iD: 0000-0002-7526-5105
PhD in Pharmaceutical Sciences, Senior Sientific Researcher, Head of Scientific Center «Med Standart LLC»
Uzbekistan, Karasarai St., 343, Tashkent, 100049Komila Zokirovna Alimkulova
Expertise and Standardization of Medicines, Medical Devices and Medical Equipment»under the Ministry of Health of the Republic of Uzbekistan
Email: komila.yusupova@mail.ru
ORCID iD: 0000-0002-7806-937X
PhD in Pharmaceutical Sciences, leading specialist of the printing department of the State Unitary Enterprise «State Center for Expertise and Standardization of Medicines, Medical Devices and Medical Equipment» under the Ministry of Health of the Republic of Uzbekistan
Uzbekistan, st. Ozod, 16, passage K. Umarov, 100002, TashkentAbdurahmon Rasuljonovich Shokodirov
«Med Standart» Research Center
Email: abdurakhmon95@gmail.com
ORCID iD: 0000-0003-0858-2159
pharmacologist of the Scientific Center of Scientific Center «Med Standart LLC»
Uzbekistan, Karasarai St., 343, Tashkent, 100049Flyura Faridovna Urmanova
Tashkent Pharmaceutical Institute
Email: flyura.urmanova@mail.ru
ORCID iD: 0009-0003-8636-5480
Professor of the Department of Pharmacognosy of Tashkent Pharmaceutical Institute, Doctor of Pharmaceutical Sciences, Professor
Uzbekistan, Aibek St., 45, Tashkent, 100015References
- Khaitov R.M. Immunomodulators: myths and reality. Immunologiya. 2020; 41 (2): 101–6. https://doi.org/10.33029/0206-4952-2020-41-2-101-106 (in Russian)
- Pinegin B.V., Khaitov R.M. Modern principles of immunotropic drugs creation. Immunologiya. 2019; 40 (6): 57–62. doi: 10.24411/0206-4952-2019-16008 (in Russian)
- Imamaliev B.A., Alimkulova K.Z., Shokodirov R.R., Isajhanov M.S., Urmanova F.F. Evaluation of the impact of immunomodulatory phytocombination as a dry extract on humoral immunity. Farmatsiya. 2021; 70 (7): 53–6. https://doi.org/10/29296/25419218-202T-07-09 (in Russian)
- Dotsenko E.A., Rozhdestvensky D.A., Yupatov G.I. Immunodeficiencies and some immunomodulating agents. Bulletin of VSMU. 2014; 13 (3): 103–20 (in Russian)
- Guidelines for pre-clinical study of medicinal products. Part 1. (by ed. A.N. Mironov). Moscow: Grief and K, 2012; 944 (in Russian)
- Gulyamov Sh.Sh., Imamaliev B.A., Mamanov B.I. Study of the bioequivalence of drugs «Laferobion» and «Viferon». Pharmaceutical Bulletin of Uzbekistan. 2019; 3: 87–90 (in Russian)
- Reference Vidal. [Electronic edition]. Access mode:http://vidal.ru (in Russian)
Supplementary files
