Theoretical and practical development of dental films based on chitosan
- Authors: Kovtun E.V.1, Stepanova E.F.1, Pogrebniak L.V.1, Pogrebnyak A.V.1, Bokov D.O.2,3, Balobanova N.P.4, Bryuzgina E.B.5, Kolyaganova O.V.5, Klimov V.V.5, Bryuzgin E.V.5, Samylina I.A.2
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Affiliations:
- Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University
- Sechenov First Moscow State Medical University
- Federal Research Center of Nutrition and Biotechnology
- University "Synergy"
- Volgograd State Technical University
- Issue: Vol 72, No 5 (2023)
- Pages: 45-51
- Section: Technology of medicines
- URL: https://journals.rcsi.science/0367-3014/article/view/142770
- DOI: https://doi.org/10.29296/25419218-2023-05-06
- ID: 142770
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Abstract
Introduction. An analysis of the current state of research in the field of creating dental films shows the need to search for new polymer bases for their production. One of the modern approaches is the combination of phytocomplexes with polymers with biological activity. Such a promising polymer, in our opinion, is chitosan, a derivative of the polysaccharide chitin and a large-tonnage product of the processing of the latter. It has a number of advantages, providing a prolonged effect and the ability to stay on the mucous surface for a long time. Another promising component of dental products is the biologically active components of ginkgo extract.
Objective. Development of theoretical and practical methods for the production of dental films based on chitosan and evaluation of their ability to absorb biologically active components of herbal preparations.
Material and methods. Chitosan (Bioprogress, М=200 kDa, degree of deacetylation – 83%, bulk density – 1.5 g/cm3); molding of film materials according to the standard method, HLB evaluation by the Davis method, molecular modeling by molecular mechanics and quantum chemistry (academic license of the HyperChem8 molecular modeling program (HyperCube (C)), academic license No. HC80SA-4-1BBF6). The strength properties of the films were determined on a ZwickiLine tensile testing machine. Soil degradation was determined in laboratory conditions, according to GOST 9.060-75
Results. Dental films based on chitosan were obtained by dissolving chitosan in water in the presence of acetic acid, followed by conversion from the acidic to the basic form with an ammonia solution and subsequent drying in a thin layer. Previously obtained extract of ginkgo was introduced either in the pre-drying stage, or by applying directly to the film. Theoretical modeling of the adsorption of biologically active components of ginkgo extract on the surface of chitosan by the semi-empirical method of quantum chemistry PM7 has been performed. The physicochemical characteristics of the films in various media, as well as their strength and biodegradation, were studied.
Conclusion. The properties of dental films based on chitosan polymer have been described theoretically and experimentally, have the necessary technological characteristics and can be used as promising dental dosage forms, including those containing ginkgo extract.
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##article.viewOnOriginalSite##About the authors
Elena V. Kovtun
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University
Author for correspondence.
Email: elena.f.73@mail.ru
ORCID iD: 0000-0003-3437-760X
PhD in Pharmaceutical Sciences, Associate Professor at the Department of Pharmaceutical Technology with a Course in Medical Biotechnology
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Eleonora F. Stepanova
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University
Email: e.f.stepanova@mail.ru
ORCID iD: 0000-0002-4082-3330
Doctor of Pharmaceutical Sciences, Professor, Professor at the Department of Pharmaceutical Technology with a Course in Medical Biotechnology
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Lyudmila V. Pogrebniak
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University
Email: pspa2010@yandex.ru
ORCID iD: 0000-0002-7846-0862
PhD in Pharmaceutical Sciences, Associate Professor at the Department of Pharmaceutical Technology with a Course in Medical Biotechnology
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Andrey V. Pogrebnyak
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University
Email: pspa2007@yandex.ru
ORCID iD: 0000-0002-6430-8018
Doctor of Chemistry, Professor of the Department of Inorganic, Physical and Colloidal Chemistry
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Dmitry O. Bokov
Sechenov First Moscow State Medical University; Federal Research Center of Nutrition and Biotechnology
Email: bokov_d_o@staff.sechenov.ru
ORCID iD: 0000-0003-2968-2466
PhD in Pharmaceutical sciences, Associate professor, Associate professor at the Pharmaceutical Natural Sciences Departmet, Institute of Pharmacy named after A.P. Nelyubin, researcher of laboratory of chemistry of food products
Russian Federation, Trubetskaya St., 8, bldg. 2, Moscow, 119991; Ustinsky proezd, building 2/14, Moscow, 109240Natalya P. Balobanova
University "Synergy"
Email: Balobanova.np@yandex.ru
ORCID iD: 0000-0003-1946-1379
PhD in Biological Sciences, Associate Professor, Head of the Department of Pharmacy, Faculty of Medicine
Russian Federation, Leningradsky Prospekt, 80, Moscow, 125190Ekaterina B. Bryuzgina
Volgograd State Technical University
Email: cherekaterina18@gmail.com
ORCID iD: 0000-0002-9627-334X
PhD in Chemical Sciences, Associate Professor at the epartment of technologies of macromolecular and fibrous materials
Russian Federation, V.I. Lenina, 28, Volgograd, 400005Olga V. Kolyaganova
Volgograd State Technical University
Email: ollik86@mail.ru
ORCID iD: 0000-0002-6004-0413
PhD in Technical Sciences, Associate Professor at the Department of technologies of macromolecular and fibrous materials
Russian Federation, V.I. Lenina, 28, Volgograd, 400005Viktor V. Klimov
Volgograd State Technical University
Email: vicklimov@gmail.com
ORCID iD: 0000-0003-3468-7528
PhD in Chemical Sciences, Associate Professor at the Department of technologies of macromolecular and fibrous materials
Russian Federation, V.I. Lenina, 28, Volgograd, 400005Evgeny V. Bryuzgin
Volgograd State Technical University
Email: cherekaterina18@gmail.com
ORCID iD: 0000-0002-2930-1910
Doctor of Chemistry, Associate Professor at the Department of technologies of macromolecular and fibrous materials
Russian Federation, V.I. Lenina, 28, Volgograd, 400005Irina A. Samylina
Sechenov First Moscow State Medical University
Email: samylina_i_a@staff.sechenov.ru
ORCID iD: 0000-0002-4895-0203
Doctor of Pharmaceutical sciences, corresponding member of the RAS, Professor, Professor of the Pharmaceutical Natural Sciences Department, Institute of Pharmacy named after A.P. Nelyubin
Russian Federation, Trubetskaya St., 8, bldg. 2, Moscow, 119991References
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