Bone Mineral Density and Molecular Genetic Markers of Bone Remodeling in Blood of Cosmonauts after Long-term Missions on Board the International Space Station
- 作者: Novikov V.1, Rykova M.1, Antropova E.1, Berendeeva T.1, Kalinin S.1, Vassilieva G.1, Ponomarev S.1
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隶属关系:
- Institute of Biomedical Problems
- 期: 卷 43, 编号 6 (2017)
- 页面: 686-692
- 栏目: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/177324
- DOI: https://doi.org/10.1134/S0362119717060068
- ID: 177324
如何引用文章
详细
The results of the investigation of the bone system of 24 Russian cosmonauts after long-term (124–199 days) missions on board the International space station (ISS) are presented. Functional adaptation of the bone system involves some complex changes in the metabolic activity of osteoblasts and osteoclasts, such as alterations of the serum concentrations of osteocalcin, tartrate-resistant acid phosphatase (TRAP), osteoprotegerin, and the activator ligand of the receptor of nuclear factor kappa-B (RANKL); in addition, in peripheral blood leucocytes, there are changes in the expression of genes regulating the development of skeletal system and bone mineral metabolism. Significant variability in the mineral density of femoral neck and molecular genetic markers studied after long-term space flights indicates individual variability of the balance of the processes of bone remodeling, bone formation and resorption. Significant bone mass losses in the femoral bone of cosmonauts are associated with more pronounced changes in the markers of metabolic activity of osteoclasts.
作者简介
V. Novikov
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
俄罗斯联邦, Moscow, 123007
M. Rykova
Institute of Biomedical Problems
编辑信件的主要联系方式.
Email: rykovamarina@yandex.ru
俄罗斯联邦, Moscow, 123007
E. Antropova
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
俄罗斯联邦, Moscow, 123007
T. Berendeeva
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
俄罗斯联邦, Moscow, 123007
S. Kalinin
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
俄罗斯联邦, Moscow, 123007
G. Vassilieva
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
俄罗斯联邦, Moscow, 123007
S. Ponomarev
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
俄罗斯联邦, Moscow, 123007