Bone Mineral Density and Molecular Genetic Markers of Bone Remodeling in Blood of Cosmonauts after Long-term Missions on Board the International Space Station
- Authors: Novikov V.E.1, Rykova M.P.1, Antropova E.N.1, Berendeeva T.A.1, Kalinin S.A.1, Vassilieva G.Y.1, Ponomarev S.A.1
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Affiliations:
- Institute of Biomedical Problems
- Issue: Vol 43, No 6 (2017)
- Pages: 686-692
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/177324
- DOI: https://doi.org/10.1134/S0362119717060068
- ID: 177324
Cite item
Abstract
The results of the investigation of the bone system of 24 Russian cosmonauts after long-term (124–199 days) missions on board the International space station (ISS) are presented. Functional adaptation of the bone system involves some complex changes in the metabolic activity of osteoblasts and osteoclasts, such as alterations of the serum concentrations of osteocalcin, tartrate-resistant acid phosphatase (TRAP), osteoprotegerin, and the activator ligand of the receptor of nuclear factor kappa-B (RANKL); in addition, in peripheral blood leucocytes, there are changes in the expression of genes regulating the development of skeletal system and bone mineral metabolism. Significant variability in the mineral density of femoral neck and molecular genetic markers studied after long-term space flights indicates individual variability of the balance of the processes of bone remodeling, bone formation and resorption. Significant bone mass losses in the femoral bone of cosmonauts are associated with more pronounced changes in the markers of metabolic activity of osteoclasts.
About the authors
V. E. Novikov
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
Russian Federation, Moscow, 123007
M. P. Rykova
Institute of Biomedical Problems
Author for correspondence.
Email: rykovamarina@yandex.ru
Russian Federation, Moscow, 123007
E. N. Antropova
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
Russian Federation, Moscow, 123007
T. A. Berendeeva
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
Russian Federation, Moscow, 123007
S. A. Kalinin
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
Russian Federation, Moscow, 123007
G. Yu. Vassilieva
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
Russian Federation, Moscow, 123007
S. A. Ponomarev
Institute of Biomedical Problems
Email: rykovamarina@yandex.ru
Russian Federation, Moscow, 123007