Comprehensive assessment of the hemostasis system in the participants of the Mars-500 experiment
- 作者: Kuzichkin D.1, Markin A.1, Vorontsov A.1, Morukov B.1, Zhuravleva O.1, Zabolotskaya I.1, Vostrikova L.1
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隶属关系:
- Institute of Biomedical Problems
- 期: 卷 42, 编号 7 (2016)
- 页面: 782-787
- 栏目: Experimental and Theoretical Studies
- URL: https://journals.rcsi.science/0362-1197/article/view/176917
- DOI: https://doi.org/10.1134/S0362119716070082
- ID: 176917
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详细
Hemostasis has been studied in the course of long-term (520 days) isolation in hermetic chamber. Measured parameters included activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin time (ТT); concentrations of fibrinogen (FBG), plasminogen (PG), Willebrand factor (WF), tissue factor pathway inhibitor (TFPI), tissue plasminogen activator (TPA), and thrombomodulin (ТМ); activities of the coagulation cascade factors II, V, VII, X, VIII, IX, XI, and XII, antithrombin III (ATIII), protein С (PC), С1-inhibitor (С1), α2-antiplasmin (АP), TPA and TFPI. The investigation revealed a diversity of changes in plasma FBG concentration, slower blood coagulation in the intrinsic pathway and in final stage, and a relative rise in the activities of ATIII and PC-inhibited factors. The remaining parameters exhibited different trends.
作者简介
D. Kuzichkin
Institute of Biomedical Problems
编辑信件的主要联系方式.
Email: dsk1685@gmail.com
俄罗斯联邦, Moscow, 123007
A. Markin
Institute of Biomedical Problems
Email: dsk1685@gmail.com
俄罗斯联邦, Moscow, 123007
A. Vorontsov
Institute of Biomedical Problems
Email: dsk1685@gmail.com
俄罗斯联邦, Moscow, 123007
B. Morukov
Institute of Biomedical Problems
Email: dsk1685@gmail.com
俄罗斯联邦, Moscow, 123007
O. Zhuravleva
Institute of Biomedical Problems
Email: dsk1685@gmail.com
俄罗斯联邦, Moscow, 123007
I. Zabolotskaya
Institute of Biomedical Problems
Email: dsk1685@gmail.com
俄罗斯联邦, Moscow, 123007
L. Vostrikova
Institute of Biomedical Problems
Email: dsk1685@gmail.com
俄罗斯联邦, Moscow, 123007