Comprehensive assessment of the hemostasis system in the participants of the Mars-500 experiment
- Authors: Kuzichkin D.S.1, Markin A.A.1, Vorontsov A.L.1, Morukov B.V.1, Zhuravleva O.A.1, Zabolotskaya I.V.1, Vostrikova L.V.1
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Affiliations:
- Institute of Biomedical Problems
- Issue: Vol 42, No 7 (2016)
- Pages: 782-787
- Section: Experimental and Theoretical Studies
- URL: https://journals.rcsi.science/0362-1197/article/view/176917
- DOI: https://doi.org/10.1134/S0362119716070082
- ID: 176917
Cite item
Abstract
Hemostasis has been studied in the course of long-term (520 days) isolation in hermetic chamber. Measured parameters included activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin time (ТT); concentrations of fibrinogen (FBG), plasminogen (PG), Willebrand factor (WF), tissue factor pathway inhibitor (TFPI), tissue plasminogen activator (TPA), and thrombomodulin (ТМ); activities of the coagulation cascade factors II, V, VII, X, VIII, IX, XI, and XII, antithrombin III (ATIII), protein С (PC), С1-inhibitor (С1), α2-antiplasmin (АP), TPA and TFPI. The investigation revealed a diversity of changes in plasma FBG concentration, slower blood coagulation in the intrinsic pathway and in final stage, and a relative rise in the activities of ATIII and PC-inhibited factors. The remaining parameters exhibited different trends.
About the authors
D. S. Kuzichkin
Institute of Biomedical Problems
Author for correspondence.
Email: dsk1685@gmail.com
Russian Federation, Moscow, 123007
A. A. Markin
Institute of Biomedical Problems
Email: dsk1685@gmail.com
Russian Federation, Moscow, 123007
A. L. Vorontsov
Institute of Biomedical Problems
Email: dsk1685@gmail.com
Russian Federation, Moscow, 123007
B. V. Morukov
Institute of Biomedical Problems
Email: dsk1685@gmail.com
Russian Federation, Moscow, 123007
O. A. Zhuravleva
Institute of Biomedical Problems
Email: dsk1685@gmail.com
Russian Federation, Moscow, 123007
I. V. Zabolotskaya
Institute of Biomedical Problems
Email: dsk1685@gmail.com
Russian Federation, Moscow, 123007
L. V. Vostrikova
Institute of Biomedical Problems
Email: dsk1685@gmail.com
Russian Federation, Moscow, 123007