The influence of chorionic gonadotropin and estriol on NK cell phenotype and functional activity
- 作者: Shirshev S.1, Nekrasova I.1, Gorbunova O.1, Orlova E.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch
- 期: 卷 42, 编号 5 (2016)
- 页面: 554-558
- 栏目: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/176752
- DOI: https://doi.org/10.1134/S0362119716050145
- ID: 176752
如何引用文章
详细
The influence of chorionic gonadotropin (CG) and estriol (Е3) at the concentrations typical of pregnancy on the expression of phenotypic markers and cytokine production by separated NK cells has been studied. It has been found that these hormones increase the percentage of CD56bright L-selectin+ NK cells, but also stimulate the expression of the inhibitory molecule NKG2A in the lymphocytes. In addition, Е3 and CG stimulate the production of TGF-β, inhibiting the secretion of all other cytokines by separated NK cells. In general, these hormones contribute to the formation of the phenotype and cytokine spectrum characteristic of the regulatory NK3 subpopulation of NK cells during pregnancy.
作者简介
S. Shirshev
Institute of Ecology and Genetics of Microorganisms, Ural Branch
编辑信件的主要联系方式.
Email: shirshev@iegm.ru
俄罗斯联邦, Perm
I. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
俄罗斯联邦, Perm
O. Gorbunova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
俄罗斯联邦, Perm
E. Orlova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
俄罗斯联邦, Perm