The influence of chorionic gonadotropin and estriol on NK cell phenotype and functional activity
- Авторлар: Shirshev S.1, Nekrasova I.1, Gorbunova O.1, Orlova E.1
-
Мекемелер:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch
- Шығарылым: Том 42, № 5 (2016)
- Беттер: 554-558
- Бөлім: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/176752
- DOI: https://doi.org/10.1134/S0362119716050145
- ID: 176752
Дәйексөз келтіру
Аннотация
The influence of chorionic gonadotropin (CG) and estriol (Е3) at the concentrations typical of pregnancy on the expression of phenotypic markers and cytokine production by separated NK cells has been studied. It has been found that these hormones increase the percentage of CD56bright L-selectin+ NK cells, but also stimulate the expression of the inhibitory molecule NKG2A in the lymphocytes. In addition, Е3 and CG stimulate the production of TGF-β, inhibiting the secretion of all other cytokines by separated NK cells. In general, these hormones contribute to the formation of the phenotype and cytokine spectrum characteristic of the regulatory NK3 subpopulation of NK cells during pregnancy.
Негізгі сөздер
Авторлар туралы
S. Shirshev
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Хат алмасуға жауапты Автор.
Email: shirshev@iegm.ru
Ресей, Perm
I. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
Ресей, Perm
O. Gorbunova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
Ресей, Perm
E. Orlova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
Ресей, Perm