Sensorimotor regulation of movements: Novel strategies for the recovery of mobility
- 作者: Gerasimenko Y.1,2, Kozlovskaya I.3, Edgerton V.2
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隶属关系:
- Pavlov Institute of Physiology
- Department of Integrative Biology and Physiology
- Institute of Biomedical Problems
- 期: 卷 42, 编号 1 (2016)
- 页面: 90-102
- 栏目: Reviews
- URL: https://journals.rcsi.science/0362-1197/article/view/176551
- DOI: https://doi.org/10.1134/S0362119716010096
- ID: 176551
如何引用文章
详细
A series of observations have provided important insight into properties of the spinal as well as supraspinal circuitries that control posture and movement. We have demonstrated that spinal rats can regain full weight-bearing standing and stepping over a range of speeds and directions with the aid of electrically enabling motor control (eEmc), pharmacological modulation (fEmc), and training [1, 2]. Also, we have reported that voluntary control movements of individual joints and limbs can be regained after complete paralysis in humans [3, 4]. However, the ability to generate significant levels of voluntary weight-bearing stepping with or without epidural spinal cord stimulation remains limited. Herein we introduce a novel method of painless transcutaneous electrical enabling motor control (pcEmc) and sensory enabling motor control (sEmc) strategy to neuromodulate the physiological state of the spinal cord. We have found that a combination of a novel non-invasive transcutaneous spinal cord stimulation and sensory-motor stimulation of leg mechanoreceptors can modulate the spinal locomotor circuitry to state that enables voluntary rhythmic locomotor movements.
作者简介
Y. Gerasimenko
Pavlov Institute of Physiology; Department of Integrative Biology and Physiology
编辑信件的主要联系方式.
Email: yuryg@ucla.edu
俄罗斯联邦, St. Petersburg, 199034; Los Angeles, CA, 90095
I. Kozlovskaya
Institute of Biomedical Problems
Email: yuryg@ucla.edu
俄罗斯联邦, Moscow, 123007
V. Edgerton
Department of Integrative Biology and Physiology
Email: yuryg@ucla.edu
美国, Los Angeles, CA, 90095