Effect of Growth Hormone Administration on the Mass and Strength of Muscles in Healthy Young Adults: A Systematic Review and Meta-Analysis
- Autores: Sergeeva K.1, Miroshnikov A.1, Smolensky A.1
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Afiliações:
- Russian State University of Physical Training, Sports, Youth and Tourism
- Edição: Volume 45, Nº 4 (2019)
- Páginas: 452-460
- Seção: Reviews
- URL: https://journals.rcsi.science/0362-1197/article/view/178275
- DOI: https://doi.org/10.1134/S0362119719030162
- ID: 178275
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Resumo
The growth hormone (GH) is prohibited for use by athletes, while its anabolic effect on muscle tissue is still debated. The review provides a systematic evaluation of the GH effects on the body composition and strength parameters in well-trained healthy young subjects. A meta-analysis of published data from randomized controlled trials (RCTs) was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Pooled results of 11 RCTs showed that GH administration significantly increases the lean body mass (2.72, 95% CI: 2.02; 3.38, p < 0.01), total water content (1.10, 95% CI: 0.54; 1.66, p < 0.01), and extracellular water (1.78, 95% CI: 1.04; 2.52, p < 0.01) and reduces the fat mass (–0.67, 95% CI: –0.93; –0.40, p < 0.01) without changing the muscle protein synthesis rate (0.00, 95% CI: –0.01; 0.02, p = 0.70) and muscle strength (–0.02, 95% CI: –0.05; 0.02, p = 0.36) as compared with placebo. A conclusion was made that GH administration can improve the body composition in healthy young subject by exerting a significant lipolytic effect without causing hypertrophy of muscle fibers. The increase in lean body mass is due to an accumulation of extracellular water.
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Sobre autores
K. Sergeeva
Russian State University of Physical Training, Sports, Youth and Tourism
Autor responsável pela correspondência
Email: sergeeva_xenia@mail.ru
Rússia, Moscow
A. Miroshnikov
Russian State University of Physical Training, Sports, Youth and Tourism
Email: sergeeva_xenia@mail.ru
Rússia, Moscow
A. Smolensky
Russian State University of Physical Training, Sports, Youth and Tourism
Email: sergeeva_xenia@mail.ru
Rússia, Moscow