Sensorimotor regulation of movements: Novel strategies for the recovery of mobility
- Авторлар: Gerasimenko Y.1,2, Kozlovskaya I.3, Edgerton V.2
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Мекемелер:
- Pavlov Institute of Physiology
- Department of Integrative Biology and Physiology
- Institute of Biomedical Problems
- Шығарылым: Том 42, № 1 (2016)
- Беттер: 90-102
- Бөлім: Reviews
- URL: https://journals.rcsi.science/0362-1197/article/view/176551
- DOI: https://doi.org/10.1134/S0362119716010096
- ID: 176551
Дәйексөз келтіру
Аннотация
A series of observations have provided important insight into properties of the spinal as well as supraspinal circuitries that control posture and movement. We have demonstrated that spinal rats can regain full weight-bearing standing and stepping over a range of speeds and directions with the aid of electrically enabling motor control (eEmc), pharmacological modulation (fEmc), and training [1, 2]. Also, we have reported that voluntary control movements of individual joints and limbs can be regained after complete paralysis in humans [3, 4]. However, the ability to generate significant levels of voluntary weight-bearing stepping with or without epidural spinal cord stimulation remains limited. Herein we introduce a novel method of painless transcutaneous electrical enabling motor control (pcEmc) and sensory enabling motor control (sEmc) strategy to neuromodulate the physiological state of the spinal cord. We have found that a combination of a novel non-invasive transcutaneous spinal cord stimulation and sensory-motor stimulation of leg mechanoreceptors can modulate the spinal locomotor circuitry to state that enables voluntary rhythmic locomotor movements.
Авторлар туралы
Y. Gerasimenko
Pavlov Institute of Physiology; Department of Integrative Biology and Physiology
Хат алмасуға жауапты Автор.
Email: yuryg@ucla.edu
Ресей, St. Petersburg, 199034; Los Angeles, CA, 90095
I. Kozlovskaya
Institute of Biomedical Problems
Email: yuryg@ucla.edu
Ресей, Moscow, 123007
V. Edgerton
Department of Integrative Biology and Physiology
Email: yuryg@ucla.edu
АҚШ, Los Angeles, CA, 90095