Toll-Like Receptors in Peripheral Blood Cells of Cosmonauts after Long-term Missions on Board the International Space Station
- Authors: Berendeeva T.A.1, Ponomarev S.A.1, Antropova E.N.1, Rykova M.P.1
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Affiliations:
- Institute for Biomedical Problems
- Issue: Vol 43, No 7 (2017)
- Pages: 802-807
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/177397
- DOI: https://doi.org/10.1134/S0362119717070039
- ID: 177397
Cite item
Abstract
Studies of Toll-like receptors (TLR) in 20 cosmonauts, members of long-term (124- to 199-day) missions on board the International Space Station showed changes in the relative and absolute counts of peripheral blood monocytes with TLR2, TLR4, and TLR6 on their surface, expression of genes TLR2 and TLR6, as well as genes of molecules involved in the TLR signaling pathway and TLR-related NF-κB-, JNK/p38- and IRF pathways on the day of return to Earth. The observed changes displayed individual variability.
About the authors
T. A. Berendeeva
Institute for Biomedical Problems
Author for correspondence.
Email: tberendeeva@mail.ru
Russian Federation, Moscow, 123007
S. A. Ponomarev
Institute for Biomedical Problems
Email: tberendeeva@mail.ru
Russian Federation, Moscow, 123007
E. N. Antropova
Institute for Biomedical Problems
Email: tberendeeva@mail.ru
Russian Federation, Moscow, 123007
M. P. Rykova
Institute for Biomedical Problems
Email: tberendeeva@mail.ru
Russian Federation, Moscow, 123007