Effects of Melatonin on the Oxygen Transport in Blood, Gas Transmitters, and Prooxidant–Antioxidant Balance in the Exercise

Abstract

We studied the effects of melatonin on the oxygen transport in blood and prooxidant−antioxidant balance in males aged from 18 to 21 years in submaximal physical exercise. The subjects received 3 mg of melatonin once a day for two months. As a result of melatonin administration, we observed a shift of oxyhemoglobin dissociation to the right, which results in reduced manifestation of oxidative stress after physical exercise. We found that the increased level of gas transmitters (nitrogen monoxide and hydrogen sulfide) after melatonin administration can influence oxygen transport in blood and prooxidant–antioxidant balance in exercise.