Trigeminal Neuralgia Associated with Herpes Zoster

Abstract

Ophthalmic nerve neuropathy (the first branch of the trigeminal nerve, CN V:V1) is the most common manifestation of herpes zoster. Ophthalmic nerve neuropathy occurs in 20% of herpes zoster cases. There are three types of pain in trigeminal neuralgia: chronic burning pain, paroxysmal pain, and pain resulting from non-painful stimulation. Cutaneous hypoesthesia, anesthesia and dysesthesia develop. Postherpetic neuralgia is characterized by pain persisting for 3 months and longer after herpetic eruption. Combination therapy including early administration of antiviral drugs and tricyclic antidepressants has been approved as the most effective.