Cell Immunity Indices in Crew Members of the Moon-2015 Project

Abstract

Cell immunity indices were studied in 6 female participants in the Moon-2015 project at the age of 25 to 34 years. Peripheral blood was analyzed for lymphocyte subtypes CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺, CD19⁺, and CD3^–CD16⁺CD56⁺ and monocytes and granulocytes that express signal recognition receptors of the Toll-like (TLR) family (TLR2, TLR4, TLR6) localized on the surface of cells. The results of the study have demonstrated a distinct effect of short-term isolation on the immune system ability to mobilize. Rotation on a short-arm centrifuge (SAC) together with a nine-day isolation in a chamber caused diverse responses of the adaptive and innate immune systems. Apparently, the changes observed reflect a complex adaptation process in the innate and acquired immunity at the early stage of adaptation to isolation and also to the exposure to +Gz accelerations (head-to-pelvis) during rotations on SAC.