L-Arginine and Its Methylated Derivatives in the Blood of Athletes
- Authors: Gilinsky M.A.1, Krivoshchekov S.G.1, Latysheva T.B.1, Naumenko S.E.1, Gilinskaya O.M.1, Aizman R.I.2, Golovin M.S.2, Balioz N.V.1, Karmakulova I.V.1
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Affiliations:
- Research Institute of Physiology and Basic Medicine
- Novosibirsk State Pedagogical University
- Issue: Vol 44, No 6 (2018)
- Pages: 679-685
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/177840
- DOI: https://doi.org/10.1134/S0362119718060063
- ID: 177840
Cite item
Abstract
The indices of the system of endogenous regulation of nitric oxide (NO) bioavailability of were compared in the group of athletes and the control group of subjects with a sedentary lifestyle. The concentrations of L-arginine (as a substrate of NO synthase and arginase) and its methylated derivatives monomethylarginine and asymmetric and symmetric dimethylarginines (MMA, ADMA and SDMA) in the blood were measured using high performance liquid chromatography (HPLC) with fluorescent detection. In parallel, some common biochemical blood parameters and the total antioxidant status were evaluated. The concentration of L-arginine in the blood plasma of athletes was 24% higher than the concentration in the control group. The levels of ADMA and SDMA were lower by 39 and 80%, respectively. The MMA level was almost two times higher than that in the control group. The total protein, bilirubin, total cholesterol, and triglyceride levels were significantly lower in athletes compared with the control. Interesting significant correlations were found between L-arginine and urea in the control group and between the Arg-to-ADMA ratio and the antioxidant activity index in the group of athletes.
About the authors
M. A. Gilinsky
Research Institute of Physiology and Basic Medicine
Author for correspondence.
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk
S. G. Krivoshchekov
Research Institute of Physiology and Basic Medicine
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk
T. B. Latysheva
Research Institute of Physiology and Basic Medicine
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk
S. E. Naumenko
Research Institute of Physiology and Basic Medicine
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk
O. M. Gilinskaya
Research Institute of Physiology and Basic Medicine
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk
R. I. Aizman
Novosibirsk State Pedagogical University
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk
M. S. Golovin
Novosibirsk State Pedagogical University
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk
N. V. Balioz
Research Institute of Physiology and Basic Medicine
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk
I. V. Karmakulova
Research Institute of Physiology and Basic Medicine
Email: m.a.gilinsky@physiol.ru
Russian Federation, Novosibirsk