Influence of Physical Activity on the Regulation of Iron Metabolism
- Authors: Tinkov A.A.1,2, Skalny A.V.1,2,3, Zaitseva I.P.1
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Affiliations:
- Demidov Yaroslavl State University
- Russian University of Peoples’ Friendship
- Aff3
- Issue: Vol 44, No 5 (2018)
- Pages: 592-599
- Section: Reviews
- URL: https://journals.rcsi.science/0362-1197/article/view/177804
- DOI: https://doi.org/10.1134/S0362119718050158
- ID: 177804
Cite item
Abstract
Intense physical activity has a significant effect on iron metabolism in the human organism. This paper is a review of world literature data focused on the mechanisms of iron metabolism regulation in the human organism, as well as the influence of intense exercise on these regulatory mechanisms. We have discussed the mechanisms of iron absorption and transport and the regulation of these processes under normal conditions. It has been found that intense exercise is accompanied by increased production of interleukin-6, a positive regulator of hepcidin production. Hepcidin, in turn, has an inhibitory effect on the expression of divalent metal transporter 1 and ferroportin, finally leading to both decreased iron absorption and iron sequestration in cells. All of the mentioned stages of iron deficiency development may be promising targets for correction of iron balance and working ability in patients exposed to intense physical activity.
Keywords
About the authors
A. A. Tinkov
Demidov Yaroslavl State University; Russian University of Peoples’ Friendship
Email: irisha-zip@yandex.ru
Russian Federation, Yaroslavl; Moscow
A. V. Skalny
Demidov Yaroslavl State University; Russian University of Peoples’ Friendship; Aff3
Email: irisha-zip@yandex.ru
Russian Federation, Yaroslavl; Moscow; All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow
I. P. Zaitseva
Demidov Yaroslavl State University
Author for correspondence.
Email: irisha-zip@yandex.ru
Russian Federation, Yaroslavl