Contribution of Adipokine Gene Expression in Mesenteric Adipose Tissue to the Pathogenesis of Insulin Resistance in Obese Patients


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Mesenteric adipose tissue, being a component of visceral adipose tissue, has a high lipolytic activity. Excessive accumulation of visceral adipose tissue increases the risk of metabolic disorders leading to severe consequences. Therefore, the aim of the presented study was to estimate the production of adipokine and proinflammatory molecules by the adipose tissue of small intestine mesentery evaluating its contribution to the formation of insulin resistance in obesity. The role of the activity of LEP, SERPINA12, RARRES2, and TNFα genes encoding leptin, vaspin, chemerin, and TNFα in adipose tissue of small intestinal mesentery in patients with abdominal obesity with a different state of carbohydrate metabolism was studied. The changes in serum/plasma content of the examined mediators that we detected are closely associated with their production in the adipose tissue of small intestinal mesentery. The revealed interrelations between the production of mediators (adipokines, proinflammatory molecules) studied with the parameters of carbohydrate metabolism indicate an important role of mesenteric adipose tissue in the formation of insulin resistance in obesity.

作者简介

M. Vulf (Vasilenko)

Baltic Federal University

编辑信件的主要联系方式.
Email: mary-jean@yandex.ru
俄罗斯联邦, Kaliningrad

D. Skuratovskaia

Baltic Federal University

Email: mary-jean@yandex.ru
俄罗斯联邦, Kaliningrad

E. Kirienkova

Baltic Federal University

Email: mary-jean@yandex.ru
俄罗斯联邦, Kaliningrad

P. Zatolokin

Baltic Federal University; Regional Clinical Hospital of the Kaliningrad region

Email: mary-jean@yandex.ru
俄罗斯联邦, Kaliningrad; Kaliningrad

N. Mironyuk

Regional Clinical Hospital of the Kaliningrad region

Email: mary-jean@yandex.ru
俄罗斯联邦, Kaliningrad

L. Litvinova

Baltic Federal University

Email: mary-jean@yandex.ru
俄罗斯联邦, Kaliningrad

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