Contribution of Adipokine Gene Expression in Mesenteric Adipose Tissue to the Pathogenesis of Insulin Resistance in Obese Patients
- Authors: Vulf (Vasilenko) M.A.1, Skuratovskaia D.A.1, Kirienkova E.V.1, Zatolokin P.A.1,2, Mironyuk N.I.2, Litvinova L.S.1
- 
							Affiliations: 
							- Baltic Federal University
- Regional Clinical Hospital of the Kaliningrad region
 
- Issue: Vol 44, No 4 (2018)
- Pages: 474-480
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/177742
- DOI: https://doi.org/10.1134/S036211971804014X
- ID: 177742
Cite item
Abstract
Mesenteric adipose tissue, being a component of visceral adipose tissue, has a high lipolytic activity. Excessive accumulation of visceral adipose tissue increases the risk of metabolic disorders leading to severe consequences. Therefore, the aim of the presented study was to estimate the production of adipokine and proinflammatory molecules by the adipose tissue of small intestine mesentery evaluating its contribution to the formation of insulin resistance in obesity. The role of the activity of LEP, SERPINA12, RARRES2, and TNFα genes encoding leptin, vaspin, chemerin, and TNFα in adipose tissue of small intestinal mesentery in patients with abdominal obesity with a different state of carbohydrate metabolism was studied. The changes in serum/plasma content of the examined mediators that we detected are closely associated with their production in the adipose tissue of small intestinal mesentery. The revealed interrelations between the production of mediators (adipokines, proinflammatory molecules) studied with the parameters of carbohydrate metabolism indicate an important role of mesenteric adipose tissue in the formation of insulin resistance in obesity.
About the authors
M. A. Vulf (Vasilenko)
Baltic Federal University
							Author for correspondence.
							Email: mary-jean@yandex.ru
				                					                																			                												                	Russian Federation, 							Kaliningrad						
D. A. Skuratovskaia
Baltic Federal University
														Email: mary-jean@yandex.ru
				                					                																			                												                	Russian Federation, 							Kaliningrad						
E. V. Kirienkova
Baltic Federal University
														Email: mary-jean@yandex.ru
				                					                																			                												                	Russian Federation, 							Kaliningrad						
P. A. Zatolokin
Baltic Federal University; Regional Clinical Hospital of the Kaliningrad region
														Email: mary-jean@yandex.ru
				                					                																			                												                	Russian Federation, 							Kaliningrad; Kaliningrad						
N. I. Mironyuk
Regional Clinical Hospital of the Kaliningrad region
														Email: mary-jean@yandex.ru
				                					                																			                												                	Russian Federation, 							Kaliningrad						
L. S. Litvinova
Baltic Federal University
														Email: mary-jean@yandex.ru
				                					                																			                												                	Russian Federation, 							Kaliningrad						
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