Correlations between some structural and functional brain parameters in subjects with high risk of schizophrenia
- Авторы: Lebedeva I.S.1, Tomyshev A.S.1, Akhadov T.A.2, Omeltchenko M.A.1, Semenova N.A.2,3, Mentschikov P.E.2, Bogdanova E.D.1, Kaleda V.G.1
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Учреждения:
- Mental Health Research Center of Russian Academy of Medical Sciences
- Research Institute of Emergency Pediatric Surgery and Traumatology
- Semenov Institute of Chemical Physics of Russian Academy of Sciences
- Выпуск: Том 43, № 4 (2017)
- Страницы: 385-390
- Раздел: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/177219
- DOI: https://doi.org/10.1134/S0362119717040089
- ID: 177219
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Аннотация
The study was aimed to the analysis of correlations between anatomic brain parameters and characteristics of neurophysiological and metabolic supportive mechanisms of cognitive functions in the patients with ultra-high risk of schizophrenia. The study comprised 30 young male patients and 30 age- and sexmatched mentally healthy subjects. We used the methods of diffusion-weighted tomography, single voxel proton MR spectroscopy, and oddball ERP recording. The statistically significant intergroup differences in the structural connectivity were confirmed in the anterior thalamic radiation of the left hemisphere. The diffusion abnormalities in this area were correlated with P300 latencies and the level of γ-aminobutyric acid (GABA).
Об авторах
I. Lebedeva
Mental Health Research Center of Russian Academy of Medical Sciences
Автор, ответственный за переписку.
Email: lebedeva-i@yandex.ru
Россия, Moscow
A. Tomyshev
Mental Health Research Center of Russian Academy of Medical Sciences
Email: lebedeva-i@yandex.ru
Россия, Moscow
T. Akhadov
Research Institute of Emergency Pediatric Surgery and Traumatology
Email: lebedeva-i@yandex.ru
Россия, Moscow
M. Omeltchenko
Mental Health Research Center of Russian Academy of Medical Sciences
Email: lebedeva-i@yandex.ru
Россия, Moscow
N. Semenova
Research Institute of Emergency Pediatric Surgery and Traumatology; Semenov Institute of Chemical Physics of Russian Academy of Sciences
Email: lebedeva-i@yandex.ru
Россия, Moscow; Moscow
P. Mentschikov
Research Institute of Emergency Pediatric Surgery and Traumatology
Email: lebedeva-i@yandex.ru
Россия, Moscow
E. Bogdanova
Mental Health Research Center of Russian Academy of Medical Sciences
Email: lebedeva-i@yandex.ru
Россия, Moscow
V. Kaleda
Mental Health Research Center of Russian Academy of Medical Sciences
Email: lebedeva-i@yandex.ru
Россия, Moscow
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