Association between relative bone mass and vitamin D receptor gene polymorphism
- Authors: Kozlov A.I.1,2, Vershubskaya G.G.1, Negasheva M.A.1
-
Affiliations:
- Moscow State University
- Perm State Humanitarian-Pedagogical University
- Issue: Vol 43, No 3 (2017)
- Pages: 320-325
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/177194
- DOI: https://doi.org/10.1134/S0362119717030100
- ID: 177194
Cite item
Abstract
The paper reports a search for association between the relative bone tissue mass (percent of total body mass, %BT) and FokI (rs10735810), BsmI (rs1544410), and TaqαI (rs731236) vitamin D receptor gene polymorphisms. The group of apparently healthy young adults born in the central and northern regions of European Russia included 61 men and 60 women aged 16–23 years. No statistical association was detected between the FokI polymorphism and %BT. The carriers of the BsmI *A allele exhibited a higher %BT (p = 0.0172) compared to the subjects bearing the BsmI *G*G allele. The subjects with the *C*CTaqαI genotype were characterized by increased %BT compared to the carriers of the *T allele (p = 0.0018). The data are in good correspondence with the results obtained in the studies involving apparently healthy representatives of Central European and Northern European populations of the corresponding age.
Keywords
About the authors
A. I. Kozlov
Moscow State University; Perm State Humanitarian-Pedagogical University
Author for correspondence.
Email: dr.kozlov@gmail.com
Russian Federation, Moscow, 119992; Perm, 614045
G. G. Vershubskaya
Moscow State University
Email: dr.kozlov@gmail.com
Russian Federation, Moscow, 119992
M. A. Negasheva
Moscow State University
Email: dr.kozlov@gmail.com
Russian Federation, Moscow, 119992