Reference values of the hemostasis system indices in cosmonauts
- Authors: Kuzichkin D.S.1, Markin A.A.1, Juravlyova O.A.1, Krivitsina Z.A.1, Vostrikova L.V.1, Zabolotskaya I.V.1
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Affiliations:
- Institute of Biomedical Problems
- Issue: Vol 43, No 1 (2017)
- Pages: 119-121
- Section: Short Communications
- URL: https://journals.rcsi.science/0362-1197/article/view/177121
- DOI: https://doi.org/10.1134/S0362119717010066
- ID: 177121
Cite item
Abstract
The values of 11 diagnostically significant hemostasis system indices were determined during the preflight (30–45 days before start) clinical and physiological examination of 39 cosmonauts aged 35 to 54 years, who were the members of the main and backup crews of missions to the International Space Station (ISS) during the period from 2007 to 2014. Since most of the cosmonauts performed several flights over this period and were repeatedly included in backup crews, each of them underwent examinations one to five times. The reference values were calculated for each of the studied indices. It was found that the reference ranges for the parameters indicative of the integral pro- and anticoagulant and fibrinolytic blood plasma potential were somewhat narrowed and close to the boundaries of general population ranges, which indicates that the cosmonauts had a relatively decreased procoagulant potential and increased regulative potential of the hemostasis system. This was probably due to the criteria of selection, physical training status, and emotional status of crew members during the preflight professional activity, when adaptive changes against stressinducing effects occur in the body. The cosmonauts who underwent strict medical examination may also have some genetic features in which they differ from the general population and which provide higher body resistance and more rapid adaptation processes.
Keywords
About the authors
D. S. Kuzichkin
Institute of Biomedical Problems
Email: andre_markine@mail.ru
Russian Federation, Moscow
A. A. Markin
Institute of Biomedical Problems
Author for correspondence.
Email: andre_markine@mail.ru
Russian Federation, Moscow
O. A. Juravlyova
Institute of Biomedical Problems
Email: andre_markine@mail.ru
Russian Federation, Moscow
Z. A. Krivitsina
Institute of Biomedical Problems
Email: andre_markine@mail.ru
Russian Federation, Moscow
L. V. Vostrikova
Institute of Biomedical Problems
Email: andre_markine@mail.ru
Russian Federation, Moscow
I. V. Zabolotskaya
Institute of Biomedical Problems
Email: andre_markine@mail.ru
Russian Federation, Moscow