Relationship between levels of brain natriuretic peptide in blood and immune response in subjects
- Authors: Dobrodeeva L.K.1, Samodova A.V.1, Karyakina O.E.1
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Affiliations:
- Institute of Physiology of Natural Adaptations, Ural Branch
- Issue: Vol 42, No 6 (2016)
- Pages: 678-686
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/176827
- DOI: https://doi.org/10.1134/S0362119716050054
- ID: 176827
Cite item
Abstract
Elevated concentrations of Nt-pro-BNP were revealed in 11% of apparently healthy subjects aged 19–24 years and 22% of middle-aged (34–55 years) subjects. An increase in Nt-pro-BNP blood concentration was detected in 90% of patients with metabolic syndrome. Elevated levels of Nt-pro-BNP in peripheral blood occur with age. Higher concentrations of the peptide were revealed in women. Inhibition of lymphocytes proliferation and differentiation accompanied by increasing concentration of Nt-pro-BNP in blood is associated with a deficiency of the IL-2 level due to increased IL-10 concentration. Immunosuppressive effect of IL-10 declares itself at the level of innate immune reactions as a decrease in blood counts of naive CD45RA+ T lymphocytes, natural killer cells, T cells with adhesion receptor (CD56+) and adhesion receptor ligand (CD62L+). To prevent a loss of the intercellular pool, the effect of Nt-pro-BNP is activated. No statistically significant correlations between the increased Nt-pro-BNP concentration in blood and the content of serum IgM, IgG, IgA, IgE, IL-6, TNF-α, IFN-γ, CEC C1q, or С3d, as well as glucose, hemoglobin, transferrin, iron, or free fatty acids were revealed in apparently healthy subjects.
About the authors
L. K. Dobrodeeva
Institute of Physiology of Natural Adaptations, Ural Branch
Email: annapoletaeva2008@yandex.ru
Russian Federation, Arkhangelsk, 163000
A. V. Samodova
Institute of Physiology of Natural Adaptations, Ural Branch
Author for correspondence.
Email: annapoletaeva2008@yandex.ru
Russian Federation, Arkhangelsk, 163000
O. E. Karyakina
Institute of Physiology of Natural Adaptations, Ural Branch
Email: annapoletaeva2008@yandex.ru
Russian Federation, Arkhangelsk, 163000