Microstructural abnormalities of the corpus callosum and fasciculus uncinatus and auditory information processing in patients with juvenile paroxysmal schizophrenia
- Authors: Lebedeva I.S.1, Karelin S.A.1,2, Ahadov T.A.3, Tomyshev A.S.1, Ublinskiy M.V.3, Semenova N.A.3,4,5, Barhatova A.N.1, Kaleda V.G.1
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Affiliations:
- Mental Health Research Center
- Moscow State University
- Research Institute for Children’s Emergency Surgery and Traumatology
- Emanuel Institute of Biochemical Physics
- Semenov Institute of Chemical Physics
- Issue: Vol 42, No 4 (2016)
- Pages: 371-375
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/176662
- DOI: https://doi.org/10.1134/S0362119716040125
- ID: 176662
Cite item
Abstract
One approach to the problem of determining the mechanisms coupling the structure and functions of the brain is studies in clinical populations aimed at assessing the presence or absence of congruence of anatomical/ morphological and functional abnormalities. Magnetic resonance imaging (MRI), including structural MRI and diffusion tensor imaging with tractography, as well as the recording of auditory event-related potentials (ERPs) in the standard two-tone oddball paradigm and the sensory gating paradigm, was conducted in 26 male patients with paroxysmal juvenile schizophrenia and 26 mentally healthy men with no family history of mental illness. MRI abnormalities have been found in the genu of the corpus callosum and fasciculus uncinatus of the left hemisphere of the patients. Reduction of the fractional anisotropy in the genu of the corpus callosum was correlated with P300 reduction in the right temporal region.
About the authors
I. S. Lebedeva
Mental Health Research Center
Author for correspondence.
Email: Lebedeva-i@yandex.ru
Russian Federation, Moscow, 115522
S. A. Karelin
Mental Health Research Center; Moscow State University
Email: Lebedeva-i@yandex.ru
Russian Federation, Moscow, 115522; Moscow, 119992
T. An. Ahadov
Research Institute for Children’s Emergency Surgery and Traumatology
Email: Lebedeva-i@yandex.ru
Russian Federation, Moscow, 119180
A. S. Tomyshev
Mental Health Research Center
Email: Lebedeva-i@yandex.ru
Russian Federation, Moscow, 115522
M. V. Ublinskiy
Research Institute for Children’s Emergency Surgery and Traumatology
Email: Lebedeva-i@yandex.ru
Russian Federation, Moscow, 119180
N. A. Semenova
Research Institute for Children’s Emergency Surgery and Traumatology; Emanuel Institute of Biochemical Physics; Semenov Institute of Chemical Physics
Email: Lebedeva-i@yandex.ru
Russian Federation, Moscow, 119180; Moscow, 119334; Moscow, 119991
A. N. Barhatova
Mental Health Research Center
Email: Lebedeva-i@yandex.ru
Russian Federation, Moscow, 115522
V. G. Kaleda
Mental Health Research Center
Email: Lebedeva-i@yandex.ru
Russian Federation, Moscow, 115522