Search for associations between G/A polymorphism of the EPAS1 gene and the maximal oxygen consumption in Russian athletes
- Authors: Bondareva E.A.1, Bleer A.N.1, Godina E.Z.1,2
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Affiliations:
- Research Institute and Museum of Anthropology
- Russian State University of Physical Education, Sport, Youth, and Tourism
- Issue: Vol 42, No 3 (2016)
- Pages: 335-338
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/176646
- DOI: https://doi.org/10.1134/S0362119716010047
- ID: 176646
Cite item
Abstract
This study investigates associations between G/A polymorphism of the epithelial PAS domain protein 1 (EPAS1) gene (rs1867785) and the maximum rate of oxygen consumption (VO2max) in male Russian athletes. The study engaged 241 male athletes from different sports; the control group of nonathletes included 92 subjects. Increased frequencies of the AA and AG genotypes of the EPAS1 gene (χ2 = 14.16, p = 0.03) were found in the cohort of male athletes. The frequencies of these alleles in the subgroups with moderate (EPAS1*A 38.1% and EPAS1*G 61.9%) and high (EPAS1*A 41.8% and EPAS1*G 58.2%) VO2max values significantly differed from those in the control group (χ2 = 7.53, p = 0.006 and χ2 = 6.58, p = 0.01, respectively). The higher aerobic capacities are probably associated with the presence of at least one minor A allele of the EPAS1 gene in the genome.
About the authors
E. A. Bondareva
Research Institute and Museum of Anthropology
Author for correspondence.
Email: bondareva.e@gmail.com
Russian Federation, Moscow
A. N. Bleer
Research Institute and Museum of Anthropology
Email: bondareva.e@gmail.com
Russian Federation, Moscow
E. Z. Godina
Research Institute and Museum of Anthropology; Russian State University of Physical Education, Sport, Youth, and Tourism
Email: bondareva.e@gmail.com
Russian Federation, Moscow; Moscow