Distribution of polymorphic variants of the GSTP1 gene involved in biotransformation of xenobiotics in Tundra Nenets and Nganasans in comparison to Russians
- Authors: Voronina E.N.1,2, Filipenko M.L.1,2, Krivoschekov S.G.3, Tiis R.P.4, Osipova L.P.4,1, Lichman D.V.4,1, Tabikhanova L.E.4, Churkina T.V.4
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Affiliations:
- Novosibirsk State University
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
- Institute of Physiology and Fundamental Medicine
- Institute of Cytology and Genetics, Siberian Branch
- Issue: Vol 42, No 2 (2016)
- Pages: 214-222
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/176599
- DOI: https://doi.org/10.1134/S036211971602016X
- ID: 176599
Cite item
Abstract
The first study on the frequencies of polymorphic variants of the GSTP1 gene encoding glutathione-S-transferase P1 in Tundra Nenets and Nganasan populations was performed. The subject of the study was the single nucleotide polymorphisms rs1695 (Ile105Val substitution in the protein sequence) and rs1138272 (Ala114Val substitution) that had previously been shown to be associated with cancer and other multifactorial diseases. The data for Tundra Nenets of the Yamalo-Nenets autonomous okrug, Nganasans of the Taimyr Peninsula, and Russian residents of the Northern Siberia were compared. The frequencies of the mutant 105Val and 114Val variants were 10.8% and 0.8% in Nganasans, 23.7% and 4.8% in Nenets, and 35.8% and 9.1% in Russian population samples, respectively. The differences within all pairs of populations were significant for each allele. These differences may characterize the population-level susceptibility to cancer and other multifactorial diseases.
About the authors
E. N. Voronina
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: ludos77@yandex.ru
Russian Federation, Novosibirsk; Novosibirsk
M. L. Filipenko
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
Email: ludos77@yandex.ru
Russian Federation, Novosibirsk; Novosibirsk
S. G. Krivoschekov
Institute of Physiology and Fundamental Medicine
Email: ludos77@yandex.ru
Russian Federation, Novosibirsk
R. P. Tiis
Institute of Cytology and Genetics, Siberian Branch
Email: ludos77@yandex.ru
Russian Federation, Novosibirsk
L. P. Osipova
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Author for correspondence.
Email: ludos77@yandex.ru
Russian Federation, Novosibirsk; Novosibirsk
D. V. Lichman
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: ludos77@yandex.ru
Russian Federation, Novosibirsk; Novosibirsk
L. E. Tabikhanova
Institute of Cytology and Genetics, Siberian Branch
Email: ludos77@yandex.ru
Russian Federation, Novosibirsk
T. V. Churkina
Institute of Cytology and Genetics, Siberian Branch
Email: ludos77@yandex.ru
Russian Federation, Novosibirsk