КАРКАСНЫЕ ЭЛЕМЕНТЫ ИЛИ СВОБОДНЫЙ ГЕЛЕОБРАЗНЫЙ МЕЖКЛЕТОЧНЫЙ МАТРИКС КАК ОБЯЗАТЕЛЬНОЕ УСЛОВИЕ ДЛЯ ПОСТРОЕНИЯ ОРГАННЫХ СТРУКТУР ПРИ РЕГЕНЕРАЦИИ

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Аннотация

За последние десятилетия было сделано необозримо большое число попыток восстановить структуру органов млекопитающих путем введения в них стволовых клеток после повреждения. Однако оказалось, что такая процедура не ведет к полноценному восстановлению. При этом известно, что в органах, обладающих способными к пролиферации паренхиматозными клетками, в некоторых случаях возможна полная регенерация (реституция). Анализ таких моделей позволяет сделать вывод, что важнейшим условием восстановления гистологических структур органа (при наличии стволового пула) является сохранение в нем каркасных структур из коллагена, служащих «направляющими рельсами» для пролиферирующих и дифференцирующихся клеток. Альтернативным условием полной реконструкции структур органа является наличие свободного «морфогенетического пространства», состоящего из гелеобразного матрикса типа эмбриональной соединительной ткани, которое имеет место в эмбриональном органогенезе или при полной регенерации у амфибий. Подходы, направленные на сохранение каркасных структур или на создание «морфогенетического пространства» могли бы радикально улучшить результаты регенерации органов как за счет местных, так и за счет экзогенных стволовых клеток.

Об авторах

В. Н Манских

НИИ физико-химической биологии имени А.Н. Белозерского, Московский государственный университет имени М.В. Ломоносова

Email: Manskikh@mail.ru
119991 Москва, Россия

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