Нейрональные экзосомы как новая система сигналинга
- Авторы: Яковлев А.А1,2
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Учреждения:
- Институт высшей нервной деятельности и нейрофизиологии РАН
- Научно-практический психоневрологический центр им. З.П. Соловьева, Департамент здравоохранения Москвы
- Выпуск: Том 88, № 4 (2023)
- Страницы: 558-568
- Раздел: Статьи
- URL: https://journals.rcsi.science/0320-9725/article/view/144658
- DOI: https://doi.org/10.31857/S0320972523040024
- EDN: https://elibrary.ru/AKCJBZ
- ID: 144658
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Аннотация
С каждым годом изучению нейрональных экзосом посвящается все больше и больше работ. Существенно исследован потенциал экзосом как диагностических маркеров для нейродегенеративных заболеваний, и похожие схемы поиска маркеров заимствованы для исследования психиатрических патологий. Выяснены основы биогенеза экзосом в разных типах клеток, активно идет исследование физиологического значения экзосом, проясняются многие аспекты сигналинга с их участием. При этом накоплены данные, указывающие на роль экзосомального сигналинга как на важный элемент межнейрональной коммуникации. Достаточно ли у нас оснований, чтобы назвать экзосомы новым неканоническим нейротрансмиттером в головном мозге? Ответу на этот вопрос посвящена данная дискуссионная работа, в которой автор представляет на суд научной общественности концепцию о возможной роли экзосом мозга как сигнальной системы.
Ключевые слова
Об авторах
А. А Яковлев
Институт высшей нервной деятельности и нейрофизиологии РАН;Научно-практический психоневрологический центр им. З.П. Соловьева, Департамент здравоохранения Москвы
Email: al_yakovlev@ihna.ru
117485 Москва, Россия;115419 Москва, Россия
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