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BIOMOLECULAR CONDENSATES IN REGULATION OF TRANSCRIPTION AND CHROMATIN ARCHITECTURE

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Recent research highlights the pivotal role of liquid-like complexes – biomolecular condensates – in gene control. Biomolecular condensates involve enhancers and gene promoters into microenvironments with specific composition, capable of both activating and repressing transcription or maintaining its appropriate level. Aside from that, condensates can influence chromatin structure and are important participants in enhancer-promoter communication. Finally, condensates represent a perspective therapeutic target, as their misregulation results in a broad spectrum of pathologies. In this review, we cover most recent as well as fundamental research establishing the role for condensates in gene expression regulation and enhancer-promoter communication.

Авторлар туралы

A. Selivanovskiy

Institute of Gene Biology, Russian Academy of Sciences; Moscow Institute of Physics and Technology; Lomonosov Moscow State University

119334 Moscow, Russia; 141700 Dolgoprudny, Russia; 119234 Moscow, Russia

S. Razin

Institute of Gene Biology, Russian Academy of Sciences; Lomonosov Moscow State University

119334 Moscow, Russia; 119234 Moscow, Russia

S. Ulianov

Institute of Gene Biology, Russian Academy of Sciences; Lomonosov Moscow State University

Email: sergey.vulyanov@gmail.com
119334 Moscow, Russia; 119234 Moscow, Russia

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