The role of Aurora B kinase in normal and cancer cells

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Abstract

Aurora kinases are essential players in the process of mammalian cell division. Intracellular events in which Aurora kinases are involved include the regulation of spindle dynamics, microtubule-kinetochore interactions, chromosome condensation and orientation during mitosis. At least three members of the Aurora family - A, B and C - have been identified in mammals. Aurora B has been shown to be essential for maintaining genomic stability and normal cell division. Mutations and dysregulation of this kinase have been implicated in tumour initiation and progression. In this review, we discuss the functions of Aurora B, the relationship between increased Aurora B activity and carcinogenesis, and the prospects for the use of Aurora B kinase inhibitors in antitumour therapy.

About the authors

E. V Titova

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

Email: ekaterina.v.titova@gmail.com
119992 Moscow, Russia

G. S Shagieva

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

119992 Moscow, Russia

V. B Dugina

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University;Faculty of Biology, Lomonosov Moscow State University

119992 Moscow, Russia;119234 Moscow, Russia

P. B Kopnin

Institute of Carcinogenesis, Blokhin National Medical Research Centre of Oncology, Public Health Ministry of Russian Federation

115478 Moscow, Russia

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