5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acids in capsular polysaccharides of acinetobacter baumannii

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Abstract

The polysaccharide capsule that surrounds the bacterial cell plays an important role in pathogenesis of infections caused by the opportunistic pathogen Acinetobacter baumannii by providing protection from external factors. Structures of the capsular polysaccharide (CPS) produced by individual A. baumannii isolates and the corresponding CPS biosynthesis gene clusters can be highly diverse but many from them are related. A large proportion of the A. baumannii CPS types contain an isomer of 5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acid. Three of these isomers, namely acinetaminic acid (L-glycero-L-altro isomer), 8-epiacinetaminic acid (D-glycero-L-altro isomer), and 8-epipseudaminic acid (D-glycero-L-manno isomer), have not been found so far in naturally-occurring carbohydrates from other species. In the CPSs of A. baumannii, the higher monosaccharides of this class carry N-acyl substituents at positions 5 and 7, and in some CPSs, the N-acetyl and N-(3-hydroxybutanoyl) groups are both present. The present review addresses the structures and genetics of biosynthesis of the CPSs of A. baumannii that contain di-N-acyl derivatives of 5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acids.

About the authors

Y. A Knirel

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: yknirel@gmail.com
117913 Moscow, Russia

A. A Kasimova

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: yknirel@gmail.com
117913 Moscow, Russia

N. P Arbatsky

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: yknirel@gmail.com
117913 Moscow, Russia

M. M Shneider

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: yknirel@gmail.com
117997 Moscow, Russia

A. V Popova

State Research Center for Applied Microbiology and Biotechnology

Email: yknirel@gmail.com
142279 Obolensk, Moscow Region, Russia

F. A Brovko

Pushchino Branch, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: yknirel@gmail.com
142290 Pushchino, Moscow Region, Russia

A. S Shashkov

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: yknirel@gmail.com
117913 Moscow, Russia

S. N Senchenkova

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: yknirel@gmail.com
117913 Moscow, Russia

A. V Perepelov

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: yknirel@gmail.com
117913 Moscow, Russia

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