Non-specific porins from the outer membrane of Yersinia pseudotuberculosis effect on mice brain cortex tissues

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Abstract

It was found that with a single immunization of OmpF and OmpC mice with Yersinia pseudotuberculosis porins, against the background of an increasing titer of specific antibodies, pathological changes develop in the deep layers of the cerebral cortex, characterized by dystrophic changes in cells. At the same time, an increased level of caspase 3 expression is observed in neurons, which indicates the induction of proapoptotic signaling pathways. The results obtained indicate the potential ability of nonspecific pore-forming proteins of the outer membrane of Gram-negative bacteria to initiate the development of degenerative changes in brain cells.

About the authors

O. Yu Portnyagina

G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences

Email: odd64@mail.ru
690021 Vladivostok, Russia

D. N Ivashkevich

A. V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch of the Russian Academy of Sciences

Email: odd64@mail.ru
690041 Vladivostok, Russia

I. V Duizen

A. V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch of the Russian Academy of Sciences

Email: odd64@mail.ru
690041 Vladivostok, Russia

L. S Shevchenko

G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences

Email: odd64@mail.ru
690021 Vladivostok, Russia

O. D Novikova

G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences

Email: odd64@mail.ru
690021 Vladivostok, Russia

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