Antiphosphatidylserine/prothrombin complex antibodies in patients with healthy pregnancies

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Resumo

Antiphosphatidylserine/prothrombin complex (aPS/PT) antibodies are an additional set of biomarkers that can be used to detect thromboembolic and obstetric complications, in addition to the traditional panel of phospholipid antibodies.

Objective: To determine aPS/PT levels in patients with healthy pregnancies.

Materials and methods: A study of serum aPS/PT IgG and IgM levels was conducted in 50 pregnant women with normal pregnancies during the first, second, and third trimesters of gestation.

Results: The median level of aPS/PT IgG in pregnant women during the first trimester was 3.77 (2.67; 5.72) U/ml; in the second trimester, it was 3.48 (2.93; 5.39) U/ml; and in the third trimester, it was 3.72 (3.02; 4.79) U/ml. The median level of aPS/PT IgM in these patients was 3.6 (2.61; 5.09) U/ml in the first trimester; 4.1 (2.65; 5.4) U/ml in the second trimester; and 5.0 (3.41; 6.38) U/ml in the third trimester. Statistically significant changes were observed only in the third trimester (p=0.018).

Conclusion: The scientific community recognizes aPS/PT among non-criterial phospholipid antibodies as a promising diagnostic marker that may enhance the effectiveness of antiphospholipid syndrome diagnosis. Further studies involving patients with complicated pregnancies are needed to determine the significance of aPS/PT and confirm their potential use in the clinical practice of obstetricians and gynecologists.

Sobre autores

Valeriya Ischuk

N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Autor responsável pela correspondência
Email: lerchonokmark@mail.ru
ORCID ID: 0000-0003-4328-2370

PhD student at the Departments of Obstetrics and Gynecology

Rússia, Moscow

Svetlana Kerchelaeva

N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: ksb65@mail.ru
ORCID ID: 0000-0002-4411-4478

Dr. Med. Sci., Professor at the Departments of Obstetrics and Gynecology, Institute of Surgery

Rússia, Moscow

Elena Aleksandrova

A.S. Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department

Email: aleksandrovaen2015@yandex.ru
ORCID ID: 0000-0003-4074-5907

Dr. Med. Sci., Head of the Laboratory of Clinical Immunology

Rússia, Moscow

Alexander Novikov

A.S. Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department

Email: irramnlab@yandex.ru
ORCID ID: 0000-0002-2738-2956

Dr. Bio. Sci., Leading Researcher at the Laboratory of Clinical Immunology

Rússia, Moscow

Ilona Khashukoeva

H.M. Berbekov Kabardino-Balkarian State University

Email: ilona_1017@mail.ru
ORCID ID: 0009-0000-4378-910X

student

Rússia, Nalchik

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