Acute intestinal infection of uncertain etiology, complicated by the development of sepsis (clinical case)

A clinical case of acute intestinal infection unspecified etiology complicated by the development of sepsis, multiple organ failure syndrome in a 29-year-old patient is presented. Despite a wide range of diagnostic and treatment options, the problem of acute intestinal infection remains relevant due to high morbidity and significant frequency of severe forms of infection. The gastrointestinal tract plays a central role in the pathogenesis of multiple organ dysfunction. Providing selective permeability, the intestinal barrier limits the systemic absorption of intraluminal microorganisms and it's toxins. Increased permeability of the intestinal barrier can cause generalization of the infectious and inflammatory process. Given the pathophysiology of acute intestinal infections and the development of septic complications, there is a need to use sensitive and non-invasive biomarkers of early disruption of the intestinal barrier in routine clinical practice for timely detection and treatment of patients with intestinal barrier dysfunction at risk of developing multiple organ dysfunction syndrome.