Macroscopic and histological analysis of the vascular wall after implantation of a self-expanding nitinol stent: results of a preclinical in vivo study
- Autores: Verkhovskaya E.V.1, Vanyurkin A.1, Panteleeva Y.1, Poplavskii E.1, Davudov A.1, Samuilovskaya S.A.1, Perminova A.1, Antonova I.V.1, Evdokimov A.2, Evdokimov S.2, Chernyavskii M.1
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Afiliações:
- V.A. Almazov National Medical Research Center Ministry of Health of the Russia
- Research and Production Enterprises «MedEng»
- Edição: Volume 35, Nº 11 (2024)
- Páginas: 18-21
- Seção: Topical Subject
- URL: https://journals.rcsi.science/0236-3054/article/view/272309
- DOI: https://doi.org/10.29296/25877305-2024-11-03
- ID: 272309
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Resumo
Objective. To perform macroscopic and histological analysis of the vascular wall after implantation of a self-expanding nitinol stent in the in vivo experiment.
Material and methods. 2 Danish Landrace pigs were selected for experimental implantation of a new self-expanding nitinol stent with an oversizing of 5–20%. Vital signs were assessed in both pigs throughout the observation period. In the postoperative period, both animals received dual antiplatelet therapy for 3 months. After 3 months, the animals underwent control angiography and ultrasound examination of the iliofemoral segment, followed by withdrawal from the experiment by euthanasia. The next step was a morphological analysis of the stented areas of the vessels.
Results. The observation period of the animals was 3 months. Throughout the entire observation period, vital signs in both animals remained within normal values. Control angiography and ultrasound examination after 3 months demonstrated patency and the absence of significant restenoses in both pigs. Morphological analysis showed no signs of damage to the vessel walls.
Conclusion. This study showed a favorable response of the animal's body to the implantation of the presented self-expanding nitinol stent with minimal neointimal hyperplasia from the inner wall of the common iliac artery in the postoperative period.
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##article.viewOnOriginalSite##Sobre autores
E. Verkhovskaya
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Autor responsável pela correspondência
Email: verkhovskayakatya@gmail.com
Rússia, Saint Petersburg
A. Vanyurkin
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Email: verkhovskayakatya@gmail.com
Rússia, Saint Petersburg
Yu. Panteleeva
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Email: verkhovskayakatya@gmail.com
Rússia, Saint Petersburg
E. Poplavskii
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Email: verkhovskayakatya@gmail.com
Rússia, Saint Petersburg
A. Davudov
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Email: verkhovskayakatya@gmail.com
Rússia, Saint Petersburg
S. Samuilovskaya
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Email: verkhovskayakatya@gmail.com
Rússia, Saint Petersburg
A. Perminova
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Email: verkhovskayakatya@gmail.com
Rússia, Saint Petersburg
I. Antonova
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Email: verkhovskayakatya@gmail.com
Rússia, Saint Petersburg
A. Evdokimov
Research and Production Enterprises «MedEng»
Email: verkhovskayakatya@gmail.com
Cand. Sci. (Tech.)
Rússia, PenzaS. Evdokimov
Research and Production Enterprises «MedEng»
Email: verkhovskayakatya@gmail.com
Cand. Sci. (Tech.)
Rússia, PenzaM. Chernyavskii
V.A. Almazov National Medical Research Center Ministry of Health of the Russia
Email: verkhovskayakatya@gmail.com
Dr. Sci. (Med.)
Rússia, Saint PetersburgBibliografia
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